柴胡舒肝颗粒醇提工艺优选  

Optimization of ethanol-extraction technology for Chaihu shugan granule

作　　者：吴晓明[1] 

机构地区：[1]常熟市中医院,江苏常熟215500

出　　处：《实用药物与临床》2016年第11期1410-1412,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的通过正交实验优选舒肝颗粒柴胡醇提制备工艺。方法采用高效液相色谱法测定柴胡中柴胡皂苷含量,以柴胡皂苷a、柴胡皂苷d的总含量及固形物提取率为考察指标,考察乙醇浓度、乙醇用量、提取时间、提取次数4个因素对提取结果的影响。结果醇提最佳工艺为7倍量70%乙醇,提取2次,每次1.5 h。结论优选的提取工艺稳定、可行,适用于工业化生产。Objective To optimize the ethanol-extraction technology of Chaihu shugan granule by orthogonal design.Methods Alcohol extractrate and the total content of saikosaponin a and saikosaponin d were taken as the indexes for investigation,and orthogonal test was carried out to study the effects of four extracting factors（alcohol density,alcohol amount,extracting time and extracting times） on the extraction technology.Results The optimum extracting conditions were 7 times amounts of 70%alcohol,extracting for 3 times and 1.5 hours each time.Conclusion The process is efficient,stable and suitable for industrialized production.

关 键 词：正交试验 柴胡皂苷A 柴胡皂苷D 柴胡舒肝颗粒 

分 类 号：R283.6[医药卫生—中药学]