含人参或三七中成药治疗缺血性中风临床应用  

Study on the application of Chinese patent medicine contained ginseng and Panax notoginseng for ischemic stroke

作　　者：李霖[1,2] 付姝菲[1,2] 华声瑜[1] 王怡[1] 赵培[1,2] 岳少乾 

机构地区：[1]天津中医药大学,天津300193 [2]天津中医药大学中医药研究院,方剂学教育部重点实验室,天津300193

出　　处：《时珍国医国药》2016年第11期2789-2792,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81202798)

摘　　要：目的 探讨含人参或三七中成药治疗缺血性中风的临床用药规律。方法 建立Excel数据库,对CNKI中国期刊全文数据库1979～2015年发表的含人参或三七中成药治疗缺血性中风的文献进行整理分析。结果 纳入分析的文献共188篇,用于缺血性中风治疗的中成药14种,以三七总皂苷制剂最为常用。79.8%的药物用于缺血性中风急性期的治疗;在对三七总皂苷制剂的研究中,65.9%的药物使用剂量在0.32～0.60g之间,87.6%的试验疗程在10～30 d。在常规治疗基础上加用三七总皂苷制剂对于缺血性中风急性期的总体疗效及安全性均较好。纳入文献的研究方法学质量较低。结论 通过对含人参或三七中成药治疗缺血性中风的文献整理分析发现：在常规治疗基础上加用三七总皂苷制剂对缺血性中风急性期的总体疗效及安全性均较好,然而目前临床研究的方法学质量较低,缺乏符合循证医学要求的高质量研究。Objective To investgate the application of Chinese Patent medicine（CPM） contained ginseng and panax notoginseng for ischemic stroke. Methods Establish excel database to put the papers which of CPM contained ginseng and Panax notoginseng for treatment of ischemic stroke in order. The papers are from CNKI Chinese periodical full - text database about 1979 - 2015. Results 14 CPMs are referred in the 188 papers, from which panax notoginseng saponins（PNS） preparations were mostly used. 79.8% of the medicine was used for the acute stage of ischemic stroke. 65.9% of the CPM dosage was between 0.32g to 0.60g, and 87.6% of the course was 10 to 30 days. PNS preparations could be added in the treatment of acute stage of ischemia stroke for its good efficacy and safety. The quality of research methodology was low in the included clinical trials. Conclusion PNS preparations are recommended in the treatment of acute ischemia stroke for its efficiency and safety, but the quality of relative clinical trials needs to be improved in the follow-up study.

关 键 词：缺血性中风 人参 三七 中成药 用药规律 

分 类 号：R259[医药卫生—中西医结合] R2-03[医药卫生—中医内科学]