基于Aprior关联规则联合多元统计的哮喘临床效方规律分析及新方发现  

Analysis on traditional Chinese medicine prescriptions treating Bronchial Asthma based on Aprior association rules combined with multivariate analysis method and discovery of new prescriptions

作　　者：陈聪[1] 谌松霖 陈孝红[1] 费莹[1] 张曼曼[1] 徐美翔 石强[3] 

机构地区：[1]江西中医药大学,江西南昌330006 [2]天津中医药大学,天津300193 [3]江西中医药大学姚荷生研究室,江西南昌330006

出　　处：《时珍国医国药》2016年第11期2799-2802,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81560637);江西省研究生创新专项资金项目(No.YC2015-S356);天津中医药大学中西医结合学院研究生教育校外创新实践基地科技创新基金项目(No.ZXYCX201510)

摘　　要：目的通过数据挖掘方式,探究哮喘临床效方用药规律。经过纳入标准,收集哮喘效方176首,涉及162味中药,累计用药1666频次。处方标准化后,采用Aprior关联规则、系统聚类分析、因子分析等多元统计方法,探讨哮喘临床效方的组方规律。对核心药物分析,确定哮喘临床用药常以补益药、清热药、化痰药及平喘药为主。得到常用二项配伍药物16组,三项配伍药物12组,四项配伍12组,结合专业知识,发现4类证型下不同的核心药物。哮喘临床效方规律的挖掘,得出的用药配伍规律及核心药物,为临床用药开阔了思路。To investigate the application of data mining in the research of the prescription of Bronchial Asthma. By the inclusion criteria, based on the analysis on 176 cases of prescriptions, involving 162 herbal medicines, the cumulative frequency of 1666. Through self-built ＂ Bronchial Asthma prescriptions database＂, the Apriori association rules,System cluster analysis and Factor analysis were adopted in order to analyze the rules of TCM prescriptions for Bronchial Asthma. Prescriptions of TCM in treatment of Bronchial Asthma is given priority to supplement formula, clearing heat drugs, also need to use phlegm - expelling and relieving asthma formula. On the other hand, determine the treatment of constipation herbal often consist of 16 groups of two relevant herbs, 12 groups of three correlated herbs and 12 groups of four correlated herbs. Coupled with professional knowledge, core drugs of different syndromes were identified. According to data mining regularly of Bronchial Asthma prescriptions, obtaining the regularity of herbal compatibility and the core herbs, which can broaden the horizon for using the medicines in the clinical.

关 键 词：哮喘 Apriori关联 临床效方 数据挖掘 

分 类 号：R2-03[医药卫生—中医学]