β1肾上腺素能受体基因多态性对高血压心肌肥厚的影响  

Influence of polymorphisms of beta 1-adrenergic receptor on cardiac hypertrophy in hypertensive patients

作　　者：张永林[1] 盛红专[2] 

机构地区：[1]盐城市滨海县人民医院心内科,江苏盐城224500 [2]南通大学附属医院心内科,江苏南通226001

出　　处：《临床荟萃》2016年第12期1324-1327,共4页Clinical Focus

摘　　要：目的探讨β1肾上腺素能受体(β1-AR)G1165C位点和A145G位点基因多态性对高血压患者心肌肥厚的影响。方法选取体检正常者115例,高血压伴心肌肥厚患者113例,高血压不伴心肌肥厚患者114例,提取外周静脉血白细胞中的DNA,运用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)。对受试者β1-AR G1165C和A145G位点的基因多态性进行检测。结果 1β1-AR 1165C等位基因的发生频率,高血压不伴心肌肥厚组78.5%、高血压伴心肌肥厚组89.8%,差异有统计学意义(P<0.05);145G等位基因的发生频率,高血压不伴心肌肥厚组16.7%、高血压伴心肌肥厚组16.8%,差异无统计学意义(P>0.05)。2高血压伴心肌肥厚组的左心室心肌质量指数,1165G等位基因者(123.78±5.12)g/m2,1165C等位基因者(154.16±47.82)g/m2,差异有统计学意义(P<0.05);145A等位基因者(150.85±46.88)g/m2,145G等位基因者(152.11±44.31)g/m2,差异无统计学意义(P>0.05)。结论β1-AR G1165C基因多态性参与高血压患者心肌肥厚的发生和肥厚程度的调节,A145G基因多态性与高血压患者的心肌肥厚无相关性。Objective To investigate influence of polymorphisms of beta 1-adrenergic receptor G1165 Csite and A145 Gsite on the cardiac hypertrophy in hypertensive patients.Methods The study mcluded healthy subjects 115 cases from simultaneous body check,hypertension patients with cardiac hypertrophy 113 cases,and hypertension patients without cardiac hypertrophy 114 cases.The polymorphisms of G1165 Csite and A145 Gsite of beta1-adrenergic receptor were detected by means of polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）.Results（1）There were significant difference between the occurrence of 1165Cbeta1-adrenergic receptor（78.5%）in hypertensive patients without cardiac hypertrophy and in hypertensive patients with cardiac hypertrophy（89.8%）.There was no significant difference between the occurrence of 145Gbeta1-adrenergic receptor（16.7%）in hypertensive patients with no cardiac hypertrophyand in hypertensive patients with cardiac hypertrophy（16.8%）.（2）There was significant difference between the left ventricular mass index of hypertensive patients with cardiac hypertrophy（123.78±5.12）g/m2 in 1165Gbeta1-adrenergic receptor,and（154.16±47.82）g/m2 in 1165Cbeta1-adrenergic receptor（P 0.05）.There was no statistical difference between the left ventricular mass index of hypertensive patients with cardiac hypertrophy.The left ventricular mass index of 145 A beta1-adrenergic receptor and 145 G beta1-adrenergic receptor were（150.85±46.88）g/m2 and（152.11±44.31）g/m2,respectively.Conclusion Polymorphisms of G1165Cbeta1-adrenergic receptor was involved in occurring cardiac hypertrophy and regulating degree of cardiac hypertrophy in hypertensive cardiac hypertrophy.There was no correlation between polymorphisms of A145 G beta1-adrenergic receptor and left ventricular hypertrophy in hypertensive patients.

关 键 词：心肌病 肥厚性 受体 肾上腺素能β1 多态性 单核苷酸 

分 类 号：R542.2[医药卫生—心血管疾病]