阿托伐他汀治疗急性缺血性脑卒中患者颈动脉粥样硬化斑块的效果观察  

Observation of the effect of atorvastatin on carotid atherosclerotic plaque in patients with acute ischemic stroke

作　　者：蔡敬杰[1] 张素芳[1] 逄涛[1] 

机构地区：[1]郑州市第一人民医院神经内科,450000

出　　处：《国际医药卫生导报》2016年第23期3620-3622,共3页International Medicine and Health Guidance News

摘　　要：目的探究阿托伐他汀用于治疗急性缺血性卒中患者颈动脉粥样硬化斑块的效果。方法选择2014年3月至2016年1月来本院就诊的150例急性缺血性卒中并颈动脉粥样硬化斑块患者。随机分组，对照组75例患者选用辛伐他汀片进行治疗，观察组75例患者选用阿托伐他汀治疗。比较两组IMT、血脂、斑块面积变化，综合分析。结果治疗后所有患者均出现颈动脉IMT变薄、斑块面积变小，与治疗前相比差异有统计学意义（P〈0．05）；观察组效果优于对照组（P〈0．05）。两组患者治疗后血清胆固醇（TC）、低密度脂蛋白（LDL-C）、三酰甘油（TG）、高密度脂蛋白（HDL-C）水平均显著优于治疗前，且观察组的变化更加明显（P〈0．05）。结论阿托伐他汀能够明显缓解患者的颈动脉粥样硬化，缩小患者的斑块面积，有效调节血脂，预防卒中的复发。Objective To explore the effect ofatorvastatin on carotid atherosclerotic plaque in patients with acute ischemic stroke. Methods 150 patients with acute ischemic stroke and carotid atherosclerosis plaque in our hospital from March 2014 to January 2016 were selected and randomly divided into two groups. 75 cases in control group were treated with simvastatin tablets, 75 cases in observation group were treated with atorvastatin. Compared the changes of IMT, blood lipid, plaque area of two groups. Results After treatment, carotid IMT of all patients became thinner, plaque area became smaller, with statistically significant differences compared with before treatment （P〈0.05）; the curative effect of observation group was better than that of control group （P〈0.05）. After treatment, the levels of serum total cholesterol （TC）, low density lipoprotein （LDL-C）, triglyceride glycerol （TG）, high density lipoprotein （HDL-C） were significantly better than those before treatment, and the changes in observation group were more obvious （P〈0.05）. Conelusious Atorvastatin can significantly relieve carotid atherosclerosis of patients, narrow the plaque area of patients, effectively regulate blood lipids, prevent the recurrence of stroke.

关 键 词：阿托伐他汀 急性缺血性卒中 颈动脉粥样硬化 

分 类 号：R543.4[医药卫生—心血管疾病]