阿加曲班治疗进展性脑梗死的临床对照研究  

Clinical controlled study of Argatroban in the treatment of progressive cerebral infarction

作　　者：陈日升[1] 王佃晖[1] 佘晓岚[1] 王琼[1] 元佳 年永恒[1] 李英明[1] 

机构地区：[1]山西省大同市第五人民医院神经内科,山西大同037006

出　　处：《临床医药文献电子杂志》2016年第36期7113-7114,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的观察阿加曲班治疗进展性脑梗死的有效性和安全性。方法选取2014年12月-2016年5月我院收治的进展性脑梗死患者60例，将其随机分为治疗组和对照组，各30例。两组均给予活血化瘀、清除自由基及脑保护治疗。治疗组加用阿加曲班，对照组加用低分子肝素。用药疗程14天，总观察时间28天。采用NIHSS评分评价患者神经功能缺损程度，采用ADL评分评估患者日常生活能力的恢复程度。结果（1）治疗组第14天和第28天，NIHSS评分及ADL评分与治疗前比较均有明显改善，差异有统计学意义（P〈0．05），治疗组的改善程度明显优于对照组。（2）治疗组14天有效率83．3％，明显高于对照组的70．00％，差异有统计学意义（P〈0．05），两组患者用药后未出现严重出血反应，肾功能异常，药物不良反应而导致的减停药的情况。结论进展性脑梗死患者采用阿加曲班治疗能有效控制病情进展，改善预后，是一种安全有效的治疗方法。Objective To evaluate the efficacy and safety of argatroban in the treatment of progressive cerebral infarction. Methods Sixty cases of progressive cerebral infarction were randomly divided into two groups： argatroban treatment group （n=30） and conventional treatment group （n=30）. A randomized controlled trial was adopted. During treatment, two groups adopt treatment of improling the brain circneation, scavenging oxygen free radicals, and other neurotrophic drugs. Treatment group was treated with venous argatroban.Conventional treatment group was given venous low-molecular-weight heparins. NIHSS scores and ADL scores were given after treatment of 14d and 28d,to assessment of patients with clinical nerve function damage degree and daily living ability. Results The scores of NIHSS and ADL with argatroban has Statistically greatly improved than the scores before curing, the treatment group was more prominent than the control one（P〈0.05）.The effective rate of the two groups： the argatroban treatment group is 83.3% and the conventional treatment group is 70.0%. There was statistical significant difference between the two groups cases （P〈0.05）. There are high security, very few clinical adverse reactions, no serious bleeding events and renal functional normalities. Conclusion It is a safe and effective method to treat patients with progressive cerebral infarction, which can effectively control the disease progression and improve the prognosis.

关 键 词：进展性脑梗死 阿加曲班 

分 类 号：R973.2[医药卫生—药品]