注射用头孢噻肟钠中2-乙基己酸检测方法研究  

Investigate the detective method with 2-ethyl hexanoic acid in cefotaxime sodium for injection

作　　者：王瑾[1] 门瑛璇[1] 许奇 李晓东[1] SU Zong-wen 

机构地区：[1]中国食品药品检定研究院,北京100050 [2]苏州市食品药品检验所,江苏苏州215104 [3]National Institute of food and drug inspection

出　　处：《临床医药文献电子杂志》2016年第37期7443-7444,7446,共3页Electronic Journal of Clinical Medical Literature

摘　　要：目的建立用离子色谱法测定注射用头孢噻肟钠中的残留2-乙基己酸的定量检测方法与气相色谱进行比较。方法20mmol／L氢氧化钾淋洗液，AS11-HC（250＊4mm）色谱柱，流速：1．2mL／min。结果2-乙基己酸浓度在0～10．28μg／mL范围内，与峰面积呈良好线性关系，Y=0．0203x-0．0004，r=0．9999。结论与气相色谱法比较离子色谱法测定头孢噻肟钠中残留的2-乙基已酸样品用量少，前处理简单、环保，分析快捷、准确。Objective Established the method for quantitative determination of the residues of 2- ethylhexanoic acid in Cefotaxime sodium for Injection by ion chromatography. And used this method compared with the gas chromatography, s method. Method The eluent solution was 20mmol/L potassium hydroxide and the flow rate was 1.2 mL/min with AS 11-HC （250＊4mm） columns. Results When 2- ethylhexanoic acid concentration was 0-10.28mg/mL, the lineary was y =0.0203x-0.0004, r =0.9999. Conclusion Compared with the gas chromatography method, Ion chromatographic determination method of 2- ethylhexanoie acid in Cefotaxime sodium for Injection used sample less, the pretreatment was simple and environmental protection, analysis was quick and accurate.

关 键 词：2-乙基己酸 离子色谱法 

分 类 号：R927[医药卫生—药学]