自噬与椎间盘退变关系的研究进展  

Progress in Association between Autophagy and Intervertebral Disc Degeneration

作　　者：敖鹏[1] 殷嫦嫦[2] 吴添龙 黄文舟[1] 程细高[1,2] 

机构地区：[1]南昌大学第二附属医院骨科,江西省骨科研究所,南昌330006 [2]九江学院基础医学院,九江市转化医学重点实验室,九江332000

出　　处：《中国细胞生物学学报》2016年第11期1382-1390,共9页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81060147)资助的课题~~

摘　　要：自噬是一种将细胞内受损、变性、衰老的细胞器或蛋白质运输到自噬溶酶体中进行降解、循环与再利用的生物学过程。近年来研究发现,细胞自噬存在于多数退行性疾病中,其中包括骨性关节炎以及椎间盘退变(intervertebral disc degeneration,IDD)。椎间盘退变是各种退行性脊柱疾病的病理基础,是导致下腰痛的主要原因。有研究发现,在退变的椎间盘细胞中存在不同水平的自噬,但是椎间盘退变中自噬的确切作用目前仍然存在争议。因此有必要深入了解髓核细胞自身的自噬作用及其对细胞生存的影响,这对退行性椎间盘疾病的预防和治疗具有重要的临床意义。该文概要地介绍了自噬作用和过程的最新研究进展,并着重总结自噬与椎间盘退变的关系。Autophagy is a life-sustaining process used by the cell to deliver cytoplasmic components to the lysosome for degradation and recycle. In recent years, It is reported that there exists autophagy in degenerative disease, including osteoarthritis and intervertebral disc degeneration （IDD）. As a main contributing factor to low back pain, IDD is the pathological basis for various debilitating spinal diseases. Either higher or lower levels of autophagy are observed in degenerative intervertebral disc （IVD） cells. Although the precise role of autophagy in disc degeneration is still controversial, but we believed that understanding the autophagy response of nucleus pulposus （NP） cells and its role in cell survival had important clinical significance in the prevention and treatment of degenerative discogenic diseases. In this review, we briefly summarize recent progress in understanding the function and process of autophagy. In particular, we focus on studies that reveal the relationship between autophagy and IVD degeneration.

关 键 词：自噬 椎间盘退变 分子机制 

分 类 号：R681.53[医药卫生—骨科学]