维生素E增加仁术脐贴3种成分的热稳定性  

Vitamine E increases the thermal stability of three constituents in Renzhu Umbilical Paste

作　　者：王超[1] 侯伟元 叶炳皇[2] 梁土亮 刘宇[1] 张军[1] 

机构地区：[1]广州中医药大学新药开发研究中心,广东广州510006 [2]中山市黄圃人民医院,广东中山528306

出　　处：《中成药》2016年第12期2581-2585,共5页Chinese Traditional Patent Medicine

基　　金：广东省省部产学研结合项目(2013B090500119);2015年高水平大学建设专项资金(2050205)

摘　　要：目的考察仁术脐贴3种成分的热稳定化方法。方法提取砂仁、苍术、肉桂、丁香挥发油,加入羊毛脂中制备贴膏剂。HPLC法测定苍术素、桂皮醛、丁香酚含有量,以其保留率为指标,恒温加速试验比较抗氧化剂维生素E（VE）、叔丁基对羟基茴香醚（BHA）、2,6-二叔丁基对甲酚（BHT）对这3种成分受热稳定性的保护作用。结果维生素E对仁术脐贴中苍术素、桂皮醛、丁香酚的保护作用均优于其他两种抗氧化剂,其适宜用量为0.15%~0.30%。结论维生素E可增加仁术脐贴的热稳定性。AIM To investigate the thermal stabilizing approaches for three constituents in Renzhu Umbilical Paste. METHODS The volatile oils extracted from Amomi Fructus,Atractlodis Rhizoma,Cinnamomi Cortex and Caryophulli Flos,were added into lanolin for preparing the paste. The contents of atractylodin,cinnamaldehyde and eugenol were determined by HPLC,whose retention rates were taken as indices in the investigation of the protective effects of antioxidants,including vitamine E（ VE）,butylated hydroxyanisole（ BHA） and 2,6-di-tert-butyl-4-methylphenol（ BHT）,on their thermal stability with reference to the constant temperature accelerated test.RESULTS Vitamine E displayed a stronger protective effect on cinnamic aldehyde,eugenol and atractylodis than another two antioxidants at 0. 15%- 0. 30% suitable dosages. CONCLUSION Vitamine E can increase the thermal stability of Renzhu Umbilical Paste.

关 键 词：仁术脐贴 苍术素 桂皮醛 丁香酚 热稳定性 抗氧化剂 HPLC 恒温加速试验 

分 类 号：R927.11[医药卫生—药学]