中空SiO_2微球的制备及其在缓/控释应用中的新进展  

Recent Advances in Fabrication and Sustained/Controlled-release Application of Hollow Silica Microspheres

作　　者：鲍艳[1] 王彤[1] 

机构地区：[1]陕西科技大学轻工科学与工程学院,西安710021

出　　处：《无机材料学报》2016年第12期1269-1278,共10页Journal of Inorganic Materials

基　　金：新世纪优秀人才支持计划(NCET-13-0885);国家自然科学基金(21376145);陕西科技大学科研创新团队项目(TD12-03)~~

摘　　要：中空二氧化硅(SiO_2)微球具有特殊的内部空腔、吸附渗透性好、物质传递可控等优异性能,可储存负载并缓慢释放药物、香精、染料、菌素等客体分子,因此在药物缓释、医学成像、环境保护以及化妆品等领域有着广阔的应用前景。根据国内外研究进展,本文归纳对比了中空SiO_2微球几种制备方法之间的优劣差异,着重阐述了其作为缓控释载体表现出的持久性和高效性,以及功能化的有机/无机杂化微球在响应性控释方面的优越性。并对中空SiO_2微球作为新型缓控释载体的发展前景进行了展望。Hollow silica （SiO2） microspheres with special interior spaces, excellent adsorption and permeability, and controllability of material deliveries are suitable for loading and releasing guest molecules of various functionalities such as drug, fragrances, dyes, bacteria, etc. More importantly, hollow silica （SiO2） microspheres have attracted much attention due to their tremendous applications in sustained drug release, medical imaging, environmental protection, and cosmetics industry. In this paper, different preparation methods of hollow silica microspheres are reviewed and compared. Besides, the persistence and efficiency of hollow silica microspheres employed as delivery carriers and superiority of functionalized organic/inorganic hybrid microspheres are emphatically summarized. Meanwhile, the vast potential for future development of hollow silica microspheres as a novel type of sustained/controlled release carriers is prospected.

关 键 词：中空SiO2微球 传统模板法 自模板法 缓释 响应性控释 综述 

分 类 号：TB34[一般工业技术—材料科学与工程]