新型天然生物碱抗癌机制研究进展  

Review on Anticancer Mechanism of New Natural Alkaloids

作　　者：李滢[1] 张紫薇[1] 李晓岩[1] 

机构地区：[1]东北林业大学生命科学学院,哈尔滨150040

出　　处：《天然产物研究与开发》2016年第11期1850-1855,共6页Natural Product Research and Development

基　　金：中央高校基本科研业务费专项资金(2572014CA23);中国博士后基金面上项目(2013M541328)

摘　　要：生物碱作为一种具有极高生物活性的天然产物,在抗癌方面发挥着日益重要的作用。随着紫杉醇、长春新碱等生物碱的应用与投产,更多的新型生物碱被发现、研究。本文综述了近五年发现的新型天然生物碱,并从诱导细胞凋亡、调控细胞周期、增加活性氧、抑制DNA拓朴异构酶等方面阐述了生物碱的抗癌机制。Alkaloids,as a natural product with high biological activities,are playing an increasingly important role in anticancer field. With the application and production of taxol and vincristine,more and more alkaloids have been found and researched. This paper reviewed several new natural alkaloids found in the recent years and illustrated the anticancer mechanism of alkaloids from the aspects of inducing cell apoptosis,regulating cell cycle,increasing reactive oxygen species（ ROS）,inhibiting of DNA topoisomerase,etc.

关 键 词：新型生物碱 抗癌机制 细胞凋亡 活性氧 端粒酶 

分 类 号：R285[医药卫生—中药学]