黏液型铜绿假单胞菌临床分布及耐药性研究  

Clinical distribution and drug resistance trend for mucus type Pseudomonas aeruginosa

作　　者：刘丽娟[1] 任玉国[1] 赵元昊[1] 姜梅杰[2] 庄伟[1] LIU Li-juan REN Yu-guo ZHAO Yuan-hao JIANG Mei-jie ZHUANG Wei(Laiwu Peoplers Hospital, Laizvu, Shandong 271100, China)

机构地区：[1]莱芜市人民医院检验科,山东莱芜271100 [2]泰安市中心医院检验科,山东泰安271000

出　　处：《中华医院感染学杂志》2016年第23期5300-5301,5317,共3页Chinese Journal of Nosocomiology

基　　金：山东省自然科学基金资助项目(ZR2013HM009)

摘　　要：目的探讨黏液型铜绿假单胞菌的临床分布特点及耐药趋势的变化,为临床合理选择抗菌药物和预防控制医院感染提供参考依据。方法对2011-2014年经实验室检测、临床确诊为黏液型铜绿假单胞菌(mPa)感染的非重复135例病例的临床资料、疾病情况、抗菌药物使用及菌株对抗菌药物耐药性等进行回顾性总结分析,数据采用WHONET 5.6软件进行统计分析。结果 mPa菌株检出数和对各种药物体外药敏试验的耐药率均呈增长趋势,特别是对左氧氟沙星、环丙沙星和哌拉西林的耐药率已高达40.00%;对亚胺培南和美罗培南仍保持较高的敏感性,耐药率均<3.00%;未出现多黏菌素耐药菌株。结论针对mPa感染患者,临床治疗选药时必须参考黏液型铜绿假单胞菌的体外药敏试验结果,结合在体内存在有生物膜的影响因素,及时调整给药方案。OBJECTIVE To investigate the clinical distribution and drug resistance trend of mucus type Pseudomonas aeruginosa,so as to provide reference to clinical reasonable selection of antimicrobial agents and the prevention and control of nosocomial infections.METHODS The general information,disease status,antibiotic use and antibiotic resistance of non-repeated 135 mucinous type Pseudomonas aeruginosa（mPa）infection cases which diagnosed by laboratory and clinical between 2011 and 2014were retrospectively analyzed.RESULTS Both the number of strains and the drug resistance rate showed an increasing trend for mPa,especially for the drug resistance rates of levofloxacin,ciprofloxacin and ciprofloxacin,which was much higher than 40.00%.Imipenem and meropenem still were high sensitive,resistance rate below 3.00%.There was no resistant strain for polimixin.CONCLUSION For the patients with mPa infection,dosing regimen should be timely adjustment according to the drug sensitivity test results in vitro,combined with the influence factors of biofilm in vivo.

关 键 词：黏液型铜绿假单胞菌 生物被膜 临床分布 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]