新型布尼亚病毒感染病原学检测与预后研究  

Infection etiology detection and prognosis of a new type Bunyaviruses

作　　者：魏艳艳[1] 邹桂舟[1] 叶珺[1] 郜玉峰[1] 夏国美[1] 李芳[1] 金蕾[1] 魏峰[2] WEI Yan-yan ZOU Gui-zhou YE Jun GAO Yu-feng XIA Guo-mei LI Fang JIN Lei WEI Feng(The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, Chin)

机构地区：[1]安徽医科大学第二附属医院肝病科,安徽合肥230032 [2]安徽大学经济学院经济统计系,安徽合肥230062

出　　处：《中华医院感染学杂志》2016年第23期5339-5341,共3页Chinese Journal of Nosocomiology

基　　金：安徽高校省级自然科学基金资助项目(KJ2014A107)

摘　　要：目的通过回顾性分析新型布尼亚病毒感染患者继发细菌或真菌感染,探索高载量新型布尼亚病毒感染与预后相关性,为临床诊治危重症患者提供参考依据。方法对医院2013年9月-2015年9月收治70例发热伴血小板减少综合征病例资料进行回顾性分析,比较病程中培养结果和布尼亚核酸检测结果与患者预后相关性,数据采用SPSS 20.0软件进行统计分析。结果患者以中老年农民为主,多在5~7月份发病,17.39%患者有明确蜱叮咬史;共分离10株病原菌,以曲霉菌为主,共3株占30.00%;23例布尼亚病毒核酸阳性,其中重症患者死亡5例,痊愈患者18例。结论出现感染性休克的患者预后差,病死率高;在诊疗过程中,宜采取有效抗感染治疗方案和对症支持治疗,尤其对于重症患者需加强实验室指标的监测和病情监护。OBJECTIVE Through the retrospective analysis of a new type Bunyaviruses infection in patients with secondary bacterial or fungal infection to probe into the correlation between high virual loads infection and prognosis,so as to provide reference for clinical diagnosis and treatment of critical patients.METHODS A retrospective study was conducted in 70 cases of severe fever with thrombocytopenia syndrome（SFTS）patients with detailed medical records,who were treated in our hospital from Sep.2013 to Sep.2015,comparing the relationship of both bacteria or fungi culture results and nucleic acid detection results to prognosis.Data was analysed using SPSS20.0.RESULTS Old farmers accounted for a large proportion,and the onset of the disease mainly occurred from May to July each year.A history of tick bites was found in 17.39% of the patients.The total of 10 strains of pathogen were isolated,mainly Aspergillus with 3strains accounting for 30.00%.There were 23 cases of positive Bunyaviruses nucleid acid,among them 5critical patients died,and 18 cases recovered.CONCLUSIONThe prognosis of patients will be poor if with septic shock,and death rate is high.In the process of treatment,effective treatment for anti-infection and symptomatic and supportive treatment should be applied,especially to strengthen the laboratory indicators monitoring and patient care.

关 键 词：新型布尼亚病毒 发热伴血小板减少综合征 布尼亚病毒核酸 

分 类 号：R515.9[医药卫生—内科学]