血清Cys C对原发性高血压患者心、肾功能损害的评估价值  

Value of Serum Cystatin C （Cys C） Level in Evaluation of Cardiac and Renal Function Impairment of Patients with Primary Hypertension

作　　者：高二祥 

机构地区：[1]陕西省榆林市星元医院,陕西榆林719000

出　　处：《医学临床研究》2016年第11期2121-2124,共4页Journal of Clinical Research

摘　　要：【目的】探讨血清胱抑素C（CysC）对原发性高血压患者心、肾功能损害的评估价值。【方法】选取2011年1月至2014年9月本院收治的186例原发性高血压患者，并分为合并心、肾功能损害组（A组，n=63）与不合并心、肾功能损害组（B组，n=123），随机选择同期来本院体检的健康成人80例为对照组（C组）。比较三组的性别、年龄、血清CysC水平及其他临床指标。采用简单线性相关和多重线性回归探讨原发性高血压患者的血清CysC与各临床指标的关系，并采用受试者工作特征（ROc）曲线下面积评价血清CysC水平及其他指标对原发性高血压患者肾功能损害的诊断价值。【结果】三组在收缩压（SBP）、舒张压（DBP）、CysC、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、血尿素氮（BUN）、血肌酐（SCr）、肾小球滤过率（GFR）、尿微量白蛋白（mALB）、左心室射血分数（LVEF）、左心室质量指数（LVMI）等指标比较，差异均有统计学意义（P〈0．05）。血清CysC水平与SCr、mALB、LVMI等指标呈正相关（P〈0．05），与GFR、LVEF等指标呈负相关（P〈0．05）。CysC、BUN、SCr、mALB的曲线下面积分别为0．752、0．673、0．688、0．620。【结论】原发性高血压合并心、肾功能损害患者的血清CysC水平明显升高，血清CysC水平可作为评估心、肾损害的相关指标之一。[Objective]To investigate the value of Serum Cystatin C （Cys C） level in the evaluation of cardiac and renal function impairment of patients with primary hypertension. [Methods] A total of 186 patients with primary hypertension from January 2011 to September 2014 were selected and divided into the complicated group with cardiac and renal function impairment （group A, n = 63） and the non complicated group （group B, n = 123）, 80 healthy adults who received healthy examination were selected as the control group over the same period of time. Gender, age, serum Cys C levels and other clinical indicators were compared among three groups. Simple linear correlation and multiple linear regression analysis were performed to investigate the relationship between serum Cys C levels and other clinical indicators in patients with primary hypertension. The area under receiver operating characteristic （ROC） curve was used to assess the diagnostic value of serum Cys C levels and other clinical indicators in patients with renal impairment. [Results] There were significant differences in systolic blood pressure （SBP）, diastolic blood pressure （DBP）, Cys C, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, blood urea nitrogen （BUN）, serum creatinine （Scr）, glomerular filtration rate （GFR）, micro urinary albumin （mALB）, left ventricular ejection fraction （LVEF）, left ventricular mass index （LVMI） among three groups （ P 〈0.05）. Serum Cys C level was positively correlated with Scr, mALB, LVMI, and negatively correlated with GFR, LVEF （ P〈0.05）. The area under ROC curve of Cys C, BUN, Scr, mALB were respectively 0.75, 0.673, 0.688, 0.620. [Conclusion] Serum Cys C levels were significantly increased in patients with primary hypertension complicated with cardiac and renal dysfunction. Thus, Serum Cys C level could be used as one of the indexes for evaluating cardiac and renal impairment.

关 键 词：半胱氨酸蛋白酶抑制剂/血液 高血压/血液 心力衰竭/病理生理学 肾功能衰竭/病理生理学 

分 类 号：R544.1[医药卫生—心血管疾病]