黄芪生脉饮联合丹参片治疗Ⅲ期糖尿病肾病的临床研究  

Clinical effect of Huangqi Shengmai decoction combined with danshen tablets on stage Ⅲ diabetic nephropathy

作　　者：郑晓熠 华健[1] 王春霞[1] 

机构地区：[1]杭州市西湖区第二人民医院中医科,浙江杭州310024

出　　处：《全科医学临床与教育》2016年第6期633-636,共4页Clinical Education of General Practice

基　　金：杭州市卫生科技计划项目(2013B44)

摘　　要：目的观察黄芪生脉饮联合丹参片对Ⅲ期糖尿病肾病患者对内生肌酐清除率(Ccr)、尿白蛋白排泄率(UAER)的影响。方法将87例符合Ⅲ期糖尿病肾病气阴两虚兼血瘀型(Ⅲ期)患者数字表随机分为治疗组和对照组,两组均进行糖尿病教育、饮食、运动及常规降糖治疗,治疗组同时予以黄芪生脉饮联合丹参片治疗,疗程3个月,检测治疗前后血糖、Ccr、UAER,评定中医证候积分的变化。结果治疗3月后,两组空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(Hb A1c)水平比较,差异均无统计学意义(t分别=1.03、1.23、1.12,P均>0.05)。治疗组治疗后的UAER、Ccr明显低于对照组治疗后,差异均有统计学意义(t分别=2.52、2.03,P均<0.05)。治疗组治疗后的中医症状积分明显低于对照组治疗后,差异有统计学意义(t=7.26,P<0.05),治疗组临床疗效明显优于对照组,差异有统计学意义(χ2=2.02,P均<0.05)。结论黄芪生脉饮联合丹参片有利于Ⅲ期糖尿病肾病患者降低尿蛋白的排泄,提高肾功能水平,缓解患者临床症状的临床疗效。Objective To observe the effects of Huangqi Shengmai docoction combined with Danshen tablets on the creatinine clearance rate （Ccr）,urinary albumin excretion rate （UAER）in patients with stage Ⅲ diabetic nephropathy. Methods Eighty-seven patients with stage Ⅲ diabetic nephropathy of qi and yin deficiency and blood stasis syndrome were randomly divided into the treatment group and the control group,both groups were received health education for diabetes,diet,exercise and routine hypoglycemic therapy. Meanwhile,the treatment group was received Huangqi Shengmai docoction combined with Danshen tablets,the treatment courses were 3 months. The change of blood glucose,Ccr,UAER and the TCM syndrome score were evaluated before and after treatment. Results After 3 months,the FBG,2hPBG,HbA1c between two groups were not statistically different （t=1.03,1.23,1.12,P〉0.05）.The UAER and Ccr of the treatment group were significantly lower than the control group （t=2.52,2.03,P〈0.05）.The TCM syndrome score of the treatment group were significantly lower than the control group （t=7.26,P〈0.05）.The clinical effective rate of the treatment group was significantly better than the control group （χ2=2.02,P〈0.05）. Conclusion Huangqi Shengmai docoction combined with Danshen tablets can significantly reduce the UAER,improve renal function and relieve clinical symptoms in patients with stage Ⅲdiabetic nephropathy.

关 键 词：糖尿病肾病 内生肌酐清除率 尿白蛋白排泄率 疗效 

分 类 号：R259[医药卫生—中西医结合] R277.5[医药卫生—中医内科学]