超高分子量聚乙烯在骨科领域的应用及基础研究进展  

Application and research advance of ultra-high molecular weight polyethylene in orthopedics

作　　者：艾承冲 蒋佳[1,2] 陈世益[1,2] 

机构地区：[1]复旦大学运动医学中心-华山医院运动医学与关节镜外科,上海200040 [2]复旦大学聚合物分子工程国家重点实验室,上海200433

出　　处：《复旦学报（医学版）》2016年第6期717-723,共7页Fudan University Journal of Medical Sciences

基　　金：国家高技术研究发展计划(863计划)(2015AA033703);国家自然科学基金(81271958;81572108;81370052)~~

摘　　要：超高分子量聚乙烯(ultra-high molecular weight polyethylene,UHMWPE)凭借其良好的拉伸强度、耐磨性、耐冲击性、化学稳定性、低密度等特性在骨科人工关节假体、骨科缝线和人工韧带等领域广泛应用。临床研究发现UHMWPE关节产品产生磨损颗粒所导致的骨质溶解是髋关节置换术后失败的主要原因,为此许多研究致力于提高它的耐磨性以及改善它的生物相容性。本文对UHMWPE在骨科的临床应用和基础研究相关进展作一综述。Ultra-high molecular weight polyethylene （UHMWPE） is applied generally in orthopedics for its good tensile strength, wear resistance, impact resistance, chemical stability and low density. The application of UHMWPE mainly lies in joint prosthesis, orthopedic suture and artificial ligament. However, osteolysis triggered mainly by UHMWPE wear particles has been one of the major problems in total hip arthroplasty, a number of studies were carried out focusing on improve its wear resistence and biocompatibility in order to achieve better clinical performance. This article summarized the application and research advance of UHMWPE in orthopedics.

关 键 词：超高分子量聚乙烯 改性 生物相容性 

分 类 号：TQ325.12[化学工程—合成树脂塑料工业]