红桂酊涂擦结合推拿手法改善膝骨关节炎疼痛的随机对照临床研究  

A Randomized Controlled Clinical Study on “Honggui Tincture” Inunction Combined with Chinese Medical Manipulation Therapy in Improving Pain of Knee Osteoarthritis

作　　者：林勋[1,2] 陈博[1] 王建平[1] 庞坚[1] 张旻[1] 王辉昊[1] 常跃文[1] 张明才[1] 詹红生[1] 

机构地区：[1]上海中医药大学附属曙光医院石氏伤科医学中心,上海市中医药研究院骨伤科研究所,上海201203 [2]马来西亚国际医药大学中医系,马来西亚吉隆坡57000

出　　处：《上海中医药大学学报》2016年第6期38-41,51,共5页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81202707);上海市进一步加快中医药事业发展三年行动计划项目(ZY3-LCPT-2-1005);上海申康医院发展中心新兴前沿技术项目(SHDC12014121);上海市科委医学重点项目(14401970402;16401970102);浦东新区中医药事业发展专项项目(PDYNZJ2015-22;PZY2015-1);浦东新区卫生;计生科技联合攻关项目(PW2013D-11)

摘　　要：目的:观察红桂酊涂擦结合中医推拿手法治疗改善膝骨关节炎疼痛的安全性及有效性。方法:将90例膝骨关节炎患者随机分为红桂酊结合手法治疗组(简称"联合组")、红桂酊涂擦组(简称"红桂酊组")和推拿手法治疗组(简称"手法组"),每组各30例。红桂酊组采用红桂酊涂擦治疗,手法组采用推拿手法治疗,联合组采用红桂酊涂擦结合推拿手法治疗,各组疗程均为4周。于治疗前、治疗后每周及治疗结束后1个月、3个月评价3组患者的疼痛视觉模拟评分(visual analogue scale,VAS),并于末次治疗后对患者的疗效和安全性进行评价。结果:治疗后及疗程结束后1个月、3个月,3组患者的VAS评分较治疗前均降低(P<0.05)。治疗3周后,联合组VAS评分低于手法组(P<0.05);治疗4周后,联合组VAS评分低于红桂酊组、手法组(P<0.05),红桂酊组VAS评分低于手法组(P<0.05)。治疗结束后1个月和3个月进行随访,联合组VAS评分低于红桂酊组、手法组(P<0.05)。疗程结束后,红桂酊组、手法组、联合组的临床总有效率分别为74.07%、71.42%、93.33%,联合组的临床疗效优于红桂酊组、手法组(P<0.05),红桂酊组和手法组疗效比较差异无统计学意义(P>0.05)。治疗全程3组患者均未出现不良反应事件。结论:红桂酊涂擦结合中医推拿手法治疗可有效缓解膝骨关节炎患者的疼痛症状,安全性好,且能保持一定时期的疗效。Objective： To observe the safety and efficacy of＂Honggui Tincture＂inunction combined with Chinese medical manipulation therapy in improving the pain of knee osteoarthritis. Methods： Ninety patients with knee osteoarthritis were randomly divided into three groups： ＂Honggui Tincture＂combined with manipulation therapy group（ abbreviated to＂combined group＂）,＂Honggui Tincture＂inunction group（ abbreviated to ＂Honggui Tincture group＂） and manipulation therapy group（ abbreviated to＂manipulation group＂）,with 30 cases in each group. The patients in the Honggui Tincture group were treated with＂Honggui Tincture＂inunction,the patients in the manipulation group were treated with Chinese medical manipulation therapy,and the patients in the combined group were treated with ＂Honggui Tincture ＂inunction combined with Chinese medical manipulation therapy,with a course of 4 weeks. The pain scores of visual analogue scale（ VAS） were assessed once per week before and after treatment and at the 1st and 3rd months follow-up. The safety and efficacy were evaluated after treatment. Results： After treatment and at the 1st and 3rd months follow-up,the VAS scores of three groups were decreased compared with before treatment（ P〈0. 05）. After 3 weeks treatment,the VAS scores of the combined group were lower than those of the manipulation group（ P〈0. 05）; after 4 weeks treatment,the VAS scores of the combined group were lower than those of the Honggui Tincture group and the manipulation group（ P〈0. 05）,the VAS scores of the Honggui Tincture group were lower than those of the manipulation group（ P〈0. 05）. At the 1st and 3rd months follow-up,the VAS scores of the combined group were lower than those of the Honggui Tincture group and the manipulation group（ P〈0. 05）. After treatment,the clinical total effective rates of the Honggui Tincture group,manipulation group and combined group were 74. 07%,71.42% and 93. 33% respectively,the effect of the combined group wa

关 键 词：膝骨关节炎 红桂酊 推拿手法 疼痛 

分 类 号：R274.9[医药卫生—中西医结合]