血清炎性生物学指标在支气管哮喘患者病情评估中的应用价值  

Application value of serum inflammatory biological indicators in the evaluation of patients with bronchial asthma

作　　者：朱天吉[1] 张卿[1] 

机构地区：[1]内蒙古医科大学附属医院呼吸内科,内蒙古呼和浩特010050

出　　处：《中国医药导报》2016年第32期117-120,共4页China Medical Herald

基　　金：内蒙古自治区自然科学基金项目(2014MS08114)

摘　　要：目的探讨血清炎性生物学指标在支气管哮喘患者中的应用价值。方法选择2015年1月~2016年1月内蒙古医科大学附属医院收治的急性发作期支气管哮喘患者50例（急性期组）、缓解期支气管哮喘患者50例（缓解期组）和健康成人50例（对照组）。比较三组患者免疫球蛋白E（Ig E）、白细胞介素（IL）-37、IL-25、IL-27和嗜酸性粒细胞阳离子蛋白（ECP）的水平差异,并分析其与第1秒用力呼吸容积（FEV1）和呼气峰流速（PEF）的关联性。结果与对照组或缓解期组比较,急性期组患者Ig E、IL-25、IL-27和ECP均显著增高,IL-37显著降低,差异均有统计学意义（P〈0.05）。与对照组比较,缓解期组患者Ig E显著增高,IL-37显著降低,差异有统计学意义（P〈0.05）。Ig E、IL-25、IL-27、ECP与FEV1、PEF均呈显著负相关（P〈0.05）;IL-37与FEV1、PEF均呈显著正相关（P〈0.05）。结论 Ig E、IL-37、IL-25、IL-27和ECP与支气管哮喘患者病情严重程度紧密相关。Objective To investigate the application value of serum inflammatory biological indicators in patients with bronchial asthma. Methods Fifty cases of patients with acute exacerbation of bronchial asthma（acute stage group）, 50 cases with remittent stage of bronchial asthma（remittent stage group） and 50 cases with healthy adults（control group）admitted to the Affiliated Hospital of Inner Mongolia Medical University from January 2015 to January 2016 were selected. The levels of immunoglobulin E（Ig E）, interleukin（IL）-37, IL-25, IL-27 and eosinophile cationic protein（ECP）among the three groups were compared, and the correlation between them and forced expiratory volume in the first second（FEV1）, peak expiratory flow（PEF） was analyzed. Results Compared with control group or remittent stage group,the levels of Ig E, IL-27, IL25 and ECP in the acute stage group were significantly increased, and the level of IL-37 was significantly decreased, the differences were all statistically significant（P〈0.05）. Compared with control group,the Ig E of remittent stage group was significantly increased, while the level of IL-37 was significantly decreased, the differences were statistically significant（P〈0.05）. Ig E, IL-25, IL-27 and ECP were negatively correlated with FEV1 and PEF（P〈0.05）; IL-37 was positively correlated with FEV1 and PEF（P〈0.05）. Conclusion Ig E, IL-37, IL-25,IL-27 and ECP are closely related to the severity of bronchial asthma.

关 键 词：支气管哮喘 炎性生物学指标 应用价值 

分 类 号：R562.250.2[医药卫生—呼吸系统]