单纯形网格法优选柿叶总黄酮自微乳处方  

Optimization of Formulation of Self-microemulsion Containing Total Flavonoids from Folium Kaki by Simplex Lattice Method

作　　者：杨露[1] 李小芳[1] 罗佳[1] 刘海霞[1] 罗开沛 林浩[1] 牟倩倩 

机构地区：[1]成都中医药大学药学院,中药材标准化教育部重点实验室,四川省中药资源系统研究与开发利用重点实验室--省部共建国家重点实验室培育基地,成都611137

出　　处：《中国实验方剂学杂志》2016年第24期13-17,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：四川省科技厅科技创新苗子工程重点项目(2016RZ0037);四川省教育厅重点项目(15ZA0094)

摘　　要：目的:采用单纯形网格法优选柿叶总黄酮自微乳的处方,为该制剂的后续研究奠定基础。方法:在制备工艺初步筛选基础上,以油相、乳化剂、助乳化剂的比例为考察因素,粒径、多分散指数及载药量为评价指标,采用单纯形网格法优选柿叶总黄酮自微乳的处方,并测定该自微乳的黏度、溶出度等基本理化性质。结果:柿叶总黄酮自微乳最佳处方为中链甘油三酸酯-聚氧乙烯氢化蓖麻油-二乙二醇乙基醚(10∶30∶60);平均粒径、多分散指数、载药量分别为32.7 nm,0.163,22.42 mg·g-1,黏度低,性质稳定,20 min累积溶出度达89.09%。结论:单纯形网格法所建数学模型预测性好,分析准确客观,为自微乳处方的优选提供了新方法。Objective： To optimize the formulation of self-microemulsion containing total flavonoids from Folium Kaki by simplex lattice method. Method： Based on screening of preparation process,taking rates of oil phase,emulsifier and co-emulsifier as factors,simplex lattice method was adopted to optimize formulation with particle size, polydispersity index and drug loading as indexes. Physicochemical properties of this selfmicroemulsion were determined,such as viscosity,dissolution and so on. Result： Optimum formulation was 10%of median chain triglyceride oil,30% of polyoxyethylene hydrogenated castor oil,60% of diethylene glycol ethyl ether. Average particle size,polydispersity index and drug loading of self-microemulsion containing total flavonoids from Folium Kaki were 32. 7 nm,0. 163 and 22. 42 mg·g- 1; physicochemical properties was stable,cumulative dissolution at 20 min was 89. 09%. Conclusion： Simplex lattice method can build a mathematical models with good prediction and objective analysis, and it can provide a new idea for optimization of self-croemusionformulation.

关 键 词：柿叶总黄酮 自微乳 单纯形网格法 芦丁 载药量 

分 类 号：R283.6[医药卫生—中药学] R284.1[医药卫生—中医学]