Morpholine triflate promoted one-pot,four-component synthesis of dihydropyrano[2,3-c]pyrazoles  

作　　者：Chen-Feng Zhou Jian-Jun Li Wei-Ke Su 

机构地区：[1]National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients,Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology [2]Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education,College of Pharmaceutical Sciences,Zhejiang University of Technology

出　　处：《Chinese Chemical Letters》2016年第11期1686-1690,共5页中国化学快报（英文版）

摘　　要：A one-pot, four-component reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes, and malononitrile was discussed using Lewis acid catalyst morpholine triflate （MorT） to afford a series of dihydropyrano[2,3-c]pyrazoles, which were generally catalyzed by organic alkalis. Moderate to excellent yields, no chromatographic purification, and evasion of environmentally hazardous solvents in the reaction process make this protocol very useful for academia and industry.A one-pot, four-component reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes, and malononitrile was discussed using Lewis acid catalyst morpholine triflate （MorT） to afford a series of dihydropyrano[2,3-c]pyrazoles, which were generally catalyzed by organic alkalis. Moderate to excellent yields, no chromatographic purification, and evasion of environmentally hazardous solvents in the reaction process make this protocol very useful for academia and industry.

关 键 词：Dihydropyrano[2 3-c]pyrazole MCRs Morpholine triflate Green chemistry Lewis acid 

分 类 号：O626.21[理学—有机化学]