Direct synthesis of α-hydroxyketone phosphates from terminal alkynes and H-phosphine oxides in the presence of PhI(OAc)2 and H2O  

作　　者：Dong-Yan Hu Meng-Shun Li Wen-Wu Zhong Jian-Xin Ji Jin Zhu Wei Wei Qiang Zhang Ming Cheng 

机构地区：[1]Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China [2]Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China [3]University of the Chinese Academy of Sciences, Beijing 100049, China [4]School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China

出　　处：《Chinese Chemical Letters》2016年第11期1691-1695,共5页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China(Nos.21172213,21302109,21402184,and 21572217)

摘　　要：A simple and highly efficient one-pot method for the construction of α-hydroxyketone phosphates from terminal alkynes and H-phosphine oxides has been developed in the presence of PhI（OAc）2 and H20. The present protocol provides an attractive approach to α-hydroxyketone phosphates in good to high yields, with the advantages of operation simplicity, the use of commercially available materials, broad substrate scope, high atom efficiency and good tolerance to scale-up synthesis.A simple and highly efficient one-pot method for the construction of α-hydroxyketone phosphates from terminal alkynes and H-phosphine oxides has been developed in the presence of PhI（OAc）2 and H20. The present protocol provides an attractive approach to α-hydroxyketone phosphates in good to high yields, with the advantages of operation simplicity, the use of commercially available materials, broad substrate scope, high atom efficiency and good tolerance to scale-up synthesis.

关 键 词：α-Hydroxyketone phosphates Alkynes H-Phosphine oxides Water Phenyliodine diacetate 

分 类 号：O627.51[理学—有机化学]