Macleayine,a new alkaloid from Madeaya cordata  

作　　者：Chun-Mei Sai Ning-Bo Qin Cui-Cui Jia Da-Hong Li Kai-Bo Wang Yue-Hu Pei Jiao Bai Zhan-Lin Li Hui-Ming Hua 

机构地区：[1]Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China

出　　处：《Chinese Chemical Letters》2016年第11期1717-1720,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.81172958);the Basic Research Subject of Key Laboratory Supported by Educational Commission of Liaoning Province of China(No.LZ2014044)

摘　　要：Macleayine （1）, a new natural occurring alkaloid with a unique spiro [furanone-piperidinedione] framework, was isolated from the aerial parts ofMacleaya cordata. Its unusual structure was established by extensive spectroscopic analyses, computer-assisted structure elucidation software （ACD/Structure Elucidator）, quantum chemistry calculations and ECD calculation. The result of virtual molecular docking predicted the compound can enhance the effects of insulin, and may be used to treat tvpe II diabetes.Macleayine （1）, a new natural occurring alkaloid with a unique spiro [furanone-piperidinedione] framework, was isolated from the aerial parts ofMacleaya cordata. Its unusual structure was established by extensive spectroscopic analyses, computer-assisted structure elucidation software （ACD/Structure Elucidator）, quantum chemistry calculations and ECD calculation. The result of virtual molecular docking predicted the compound can enhance the effects of insulin, and may be used to treat tvpe II diabetes.

关 键 词：Macleayine A natural occurring alkaloid Quantum chemistry calculations ECD calculation Plausible biogenetic pathway Macleaya cordata 

分 类 号：TQ464.4[化学工程—制药化工]