三七断骨巴布膏用于KOA对症状改善情况及其对关节功能的影响  

The effect of pseudo-ginseng cataplasm for union of fractured bones on improving symptoms and joint function of KOA

作　　者：夏琴[1] 曹文佳[1] 陆建春[2] 陈冰[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院药剂科,上海200025 [2]上海交通大学医学院附属瑞金医院康复科,上海200025

出　　处：《现代医学》2016年第10期1411-1414,共4页Modern Medical Journal

摘　　要：目的：探讨三七断骨巴布膏对膝骨关节炎（KOA）患者症状改善作用及对关节功能的影响。方法：我院于2014年1月至2015年1月收治的150例KOA患者依据简单随机数字法平均分为两组,对照组75例采用复方水杨酸甲酯苯海拉明喷雾剂治疗,观察组75例采用三七断骨巴布膏治疗,比较两组患者临床症状和关节功能评分。结果：观察组治疗有效率为91.9%,对照组治疗有效率为79.7%,两组治疗有效率差异具有统计学意义（χ24.49,P=0.03）;观察组与对照组治疗前的视觉模拟评分法（VAS）评分、西安大略和麦马斯特大学骨关节炎指数可视化量表（WOMAC指数）和临床症状综合评分差异无统计学意义（P〉0.05）,两组患者治疗后,VAS评分、WOMAC指数和临床症状综合评分较治疗前显著下降（P〈0.05）,观察组与对照组治疗后的VAS评分、WOMAC指数和临床症状综合评分差异具有统计学意义（P〈0.05）;两组患者经治疗后关节活动功能评分显著增加（P〈0.05）,且观察组治疗后评分优于对照组（P〈0.05）;观察组2例出现皮肤不良反应（2.7%）,对照组7例出现皮肤不良反应（9.5%）,两组患者不良反应率差异具有统计学意义（χ2=10.34,P=0.00）。结论：三七断骨巴布膏能够缓解KOA临床症状、改善患者膝关节功能,疗效确切,使用方便,不良反应少,在临床应用中具有一定的优势。Objective： To investigate the influence of pseudo-ginseng cataplasm for union of fractured bones for symptoms and joint function of knee osteoarthritis（ KOA） patients. Methods： 150 cases of KOA patients in our hospital from January 2014 to January 2015 were randomly divided into two groups： the patients in control group were treated with methyl salicylate compound diphenhydramine sprays,the patients in the observation group were treated with pseudo-ginseng cataplasm for union of fractured bones,the clinical symptoms and joint function score were compared between two groups. Results： The effective rate in observation group was 91. 9%,which was higher than that in control group（ 79. 7%）（ χ~2= 4. 49,P = 0. 03）. There were no statistically significant differences in VAS score,WOMAC index and clinical symptoms comprehensive score between observation group and control group before treatment（ P 〉 0. 05）,and VAS score,WOMAC index and clinical symptoms comprehensive score were significantly decreased after treatment（ P 〈 0. 05）,but all scores in observation group were significantly improved than those in control group（ P 〈 0. 05）. Joint function scores in the two groups after treatment were significantly increased（ P 〈0. 05）,and which in the observation group was higher than that in the control group（ P 〈 0. 05）. Adverse reaction rate in observation group was 2. 7%,which was lower than that in control group（ 9. 5%）（ χ2= 10. 34,P = 0. 00）.Conclusion： Pseudo-ginseng cataplasm for union of fractured bones can alleviate symptoms of KOA patients with fewer adverse reactions,and improve joint function,be easy to use,which has certain advantages in clinical application.

关 键 词：三七断骨巴布膏 膝骨性关节炎 疗效 

分 类 号：R684.3[医药卫生—骨科学]