重庆市公共卫生医疗救治中心ART情况分析  

Analysis ofactive antiretroviral therapy(ART) treatment in Chongqing Infectious Disease Medical Center

作　　者：肖文秀[1] 聂欢 张崔晋怡 白艳[1] 唐德谊 蒋平[1] 赵攀[3] 黄成瑜 

机构地区：[1]重庆市公共卫生医疗救治中心感染科,400038 [2]重庆市公共卫生医疗救治中心项目办,400038 [3]重庆市公共卫生医疗救治中心科教科,400038

出　　处：《重庆医学》2016年第34期4795-4797,共3页Chongqing medicine

基　　金：中国-默沙东艾滋病防治合作项目(二期)

摘　　要：目的统计分析该中心2004～2014年治疗人类免疫缺陷病毒感染者／艾滋病患者（HIV／AIDs）的抗病毒治疗（ART）情况。方法采用回顾性研究，通过中国疾病预防控制信息系统中的艾滋病综合防治信息系统收集HIV／AIDs的ART数据信息并进行分析。结果2004～2014年累计治疗1856例艾滋病患者，对其随访情况进行统计，在治患者87．0％，死亡0．6％。根据纳入和删除标准，最终研究分析1504例病例，男84．2％，女15．8％；平均年龄（39．17±13．36）岁；75．8％患者通过性接触途径感染；79．7％患者基线CD4小于350个／μL。免疫学效果分析显示，同基线时相比，不同治疗时间病例的CD4淋巴细胞计数均明显升高，差异均有统计学意义（均P〈0．05）。治疗时间为1～2年的患者，CD4淋巴细胞平均增加149．8个／μL。病毒学效果分析显示，接受治疗的HIV／AIDs最近一次病毒载量（VL）检测结果中，1460例（占97．1％）小于400copy／mL，病毒得到抑制。接受ART0～6、6～12、12～24年时，病毒抑制率分别为90．0％、94．5％、98．2％。结论该中心收治HIV／AIDs例数日趋增长，但病毒学抑制率较高、免疫学应答较好，在重庆市ART中取得了较好的成绩。Objective To analysis the active antiretroviral therapy（ART） treatment from 2004 to 2014 in Chongqing Infectious Disease Medical Center. Methods A retrospective cohort analysis was conducted on the HIV/AIDS patients who started ART during 2004 to 2014 in Chongqing Infectious Disease Medical Center,and the date of cases were obtained from HIV/AIDS eompre- hend-sive information system. Results From 2004 to 2014,a total of 1856 patients were treated,by the end of 2014,87.0% of the cumulative 1856 patients had been continuing the treatment and 0.6 % of the patients died. According to the criteria of inclusion and deletion,1504 cases were selected for the study,including84.2% males and 15.8% females. The average age was （39.17±113.36）, 75.8 % of the cases were infected by sexual contact. At the baseline, 79.7% with CD4 lymphocyte count 〈350 cells/μL. The immunological effects analysis showed that the CD4 lymphocyte counts were significantly higher in patients than at baseline （P〈0.05 for all）. When patients received treatment for 1 years to 2 years,the average CD4 lymphocyte increased by 149, 8 cells/μL. Of 1504 patients completing ART treatment, 1460 had viral load 〈400 copy/mL, with a viral inhibitory rate of 97.1%. After 6 months, 1 year, 2 years on ART treatment, the virus inhibition rate was 90.0 %, 94.5% and 98.2%, respectively. Conclusion The number of HIV/AIDS is increasing in the number of days in Chongqing Infectious Disease Medical Center, but the virus inhibition rate and im- mune response are higher. It has achieved good results in the treatment of ART in Chongqing.

关 键 词：HIV 获得性免疫缺陷综合征 病毒载量 抗病毒治疗 CD4细胞 

分 类 号：R512.91[医药卫生—内科学]