5-氨基酮戊酸光动力疗法及重组人干扰素α-2b凝胶治疗宫颈高危型HPV持续感染的疗效观察  

Efficacy analysis of 5 - aminolevulinic acid photodynamic therapy and recombinant interferon α- 2b gel for treatment of cervical high risk human papilloma virus persistent infection

作　　者：陶友仙 段振玲[1] 鲁潇凝[2] 许妙龄 秦浩[2] 陈绍华[2] 

机构地区：[1]昆明医科大学第一附属医院妇科,云南昆明650031 [2]昆明医科大学第一附属医院皮肤科,云南昆明650031

出　　处：《皮肤病与性病》2016年第6期391-393,共3页Dermatology and Venereology

摘　　要：目的探讨5-氨基酮戊酸光动力疗法及重组人干扰素α-2b凝胶治疗宫颈高危型HPV持续感染的疗效。方法将高危型HPV阳性(>1年)的患者102例纳入空白对照组15例、光动力治疗组36例、干扰素治疗组51例。治疗选择非月经期,光动力治疗组每2周治疗一次,连续治疗3次;干扰素治疗组每日或隔日用药1次,每次用量为10万U,每个月经周期使用10次,共用3个月;两组治疗后进入随访期,空白对照组不做处理直接随访,每3月随访1次,至少随访9月,观察HPV阴转情况。结果第3、6、9月随访时HPV阴转率:空白对照组分别为:0、6.6%、13.3%;光动力治疗组分别为:52.8%、71.4%、80.6%;干扰素治疗组分别为:27.5%、44.4%、53.6%。光动力治疗组及干扰素治疗组HPV阴转率均高于空白对照组,差异有统计学意义;光动力治疗组HPV阴转率高于干扰素治疗组,差异有统计学意义。结论 5-氨基酮戊酸光动力疗法及重组人干扰素α-2b凝胶治疗宫颈高危型HPV持续感染均有疗效,且光动力疗法疗效优于重组人干扰素α-2b凝胶,是治疗宫颈高危型HPV持续感染的理想选择。Objective Discussion the efficacy of 5-aminolevulinic acid photodynamic therapy combined and interferon α-2b gel for treatment of cervical high-risk HPV persistent infection. Methods Selected 102 cases of patients which infected with high-risk HPV more than one year , 15 cases included in the control group, 36 cases included in the photodynamic therapy group, 51 cases included in the Interferon therapy group. Timing of treatment selected non -menstrual period, repeatly treated once every two weeks, until treatment for 3 times in photodynamic therapy group. Interferon therapy group medication once daily or every other day, every time the amount of 100,006 U, used 10 times each menstrual cycle, persistence for 3 months. After treatment, both groups went into the follow-up period, the control group directly into the follow-up period without any treatment. Follow-up once every 3 months for at least 9 months If HPV eliminated or not. Results HPV eliminated rate of the 3th,6th,9th month of follow-up period, control group are： 0, 6.6%, 13.3% ; Photodynamic Therapy group are： 52. 8%, 71.4%, 80. 6% ; Interferon therapy group are： 27.5%, 44. 4%, 53.6%. HPV eliminated rate of photodynamic therapy group and Interferon therapy group are higher than control group which are statistically significant. HPV eliminated rate of photodynamic therapy group is higher than Interferon therapy group that had statistically significant. Conclusion 5 - Aminolevulinic Acid Photodynamic Therapy and Recombinant Interferon α-2b gel treatment of high-risk HPV persistent infection do have effect. And the efficacy of Photodynamic Therapy is better than Interferon , also it is the ideal choice for the treatment of cervical high-risk HPV persistent infection.

关 键 词：人乳头瘤病毒 宫颈上皮内瘤变 光动力疗法 干扰素 

分 类 号：R711.74[医药卫生—妇产科学] R711.05[医药卫生—临床医学]