代谢综合征痰证与胰岛素抵抗指数、血脂及BMI的相关性研究  

Study on Relationship of Phlegm Syndrome of TCM with HOMA-IR, Blood Lipid and BMI in Metabolic Syndrome

作　　者：庄耀东 王永发[1] 陈晓红[1] 李雅静[1] 李灿东[2] 高碧珍 

机构地区：[1]福建中医药大学附属晋江中医院,福建晋江362200 [2]福建中医药大学,福建福州350122 [3]福建省中医健康状态辨识重点实验室,福建福州350122

出　　处：《中医药临床杂志》2016年第11期1600-1602,共3页Clinical Journal of Traditional Chinese Medicine

基　　金：福建省卫生厅中医药科技项目资助课题(编号wztn201309)

摘　　要：目的:探讨代谢综合征痰证与胰岛素抵抗指数、血脂及BMI的关系。方法:采集280例代谢综合征患者的中医四诊资料,应用"证素辨证"方法计算痰证积分,同时检测身高、体重、血脂、空腹血糖(FBG)、胰岛素,计算体重指数(BMI)及胰岛素抵抗指数(HOMA-IR)。结果:与非痰证组相比,痰证组患者的BMI、HOMA-IR明显升高,差异均有统计学意义(P<0.05),而年龄、FBG和血脂的差异无统计学意义(P>0.05)。痰证积分与BMI、HOMA-IR呈显著正相关(P<0.01或P<0.05)。Logistic回归分析显示:饮酒、熬夜、BMI、HOMA-IR是痰证的危险因素。结论:代谢综合征"痰证"从病理机制上与胰岛素抵抗有一致性;BMI、HOMA-IR可作为代谢综合征中医痰证的客观化辨证指标。Objective To investigate relationship of phlegm syndrome of TCM with HOMA-IR, blood lipid and BMI in metabolic syndrome （ MS ）. Methods The information of 280 cases of MS was collected by four diagnostic methods, syndrome differentiation by syndrome element was used to analyze the score of phlegm syndrome, and height, weight, blood fat, fasting blood-glucose （ FBG ）,insulin, BMI and HOMA-IR were detected. Results BMI and HOMA-IR of MS phlegm group were higher than that of non-phlegm group （ P〈0.05 ）, while significant difference was not found in age, FBG and blood fat （ P〉0.05 ）. There was a significant positive correlation between the score of phlegm syndrome and BMI or HOMA-IR （ P〈0.01 or P〈0.05 ） .Logistic regression analysis showed that alcohol consumption, staying up late, BMI and HOMA-IR were risk factors for MS. Conclusion Phlegm syndrome in metabolic syndrome had consistency with insulin resistance on pathological mechanism. BMI and HOMA-IR can be used as objective indicators for phlegm syndrome differentiation.

关 键 词：代谢综合征 痰证 胰岛素抵抗指数 血脂 BMI 

分 类 号：R259[医药卫生—中西医结合]