虎门合剂对成瘾模型及戒断大鼠GABA免疫阳性神经元的影响  

Influences from Traditional Chinese HuMen Composition on GABA Immune Positive Neurons of Morphine-Dependence and Withdrawal Rats

作　　者：丁尤放 林涵[1] 李树春[1] 

机构地区：[1]中央民族大学少数民族传统医学研究院,北京100081

出　　处：《中国民族民间医药》2016年第22期15-18,共4页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:研究吗啡成瘾性和戒断大鼠在虎门合剂给药后GABA阳性神经元数量的变化。方法:通过提升传统建模方法建立大鼠成瘾模型和模型评估系统,同时利用免疫组化法观察虎门合剂给药后吗啡成瘾和戒断大鼠阳性细胞元的变化。结果:吗啡依赖大鼠海马CA1区和齿状回GABA阳性神经元数目明显减少,虎门合剂治疗组海马GABA阳性神经元数量和光密度均显著升高。结论:虎门合剂对吗啡损伤一般记忆的效应具有拮抗作用。Objective To discuss the changes occurring in GABA positive neurons of morphine-dependence and withdrawal Rats after given HuMen Composition.Methods Rats addiction models and model evaluation system were established in the study through im-proving the traditional methods of building models.At the same time,immunohistochemical method was used to observe the changes occurring in positive neurons of morphine-dependence and withdrawal Rats after given HuMen Composition.Results the number of positive neurons is obviously decreased in hippocampus CA1 and Dentate Gyrus areas of morphine-dependent rats.In the treatment group of HuMen Composition,the number of hippocampus GABA and optical density are all increased respectively.Conclusion Hu-Men Composition may have certain antagonistic effect in curing damaged memory induced by morphine.

关 键 词：物质依赖 γ-氨基丁酸(GABA) 海马 神经元 虎门合剂 

分 类 号：R965[医药卫生—药理学]