昆虫胸腺素超家族蛋白研究进展  

Research Progress of Insect Thymosin Super-Family Proteins

作　　者：张晨[1] 吴业卿[1] 方强[1] 王永娣[1] 张文平[1,2] 

机构地区：[1]浙江理工大学生命科学学院,浙江杭州310018 [2]浙江省家蚕生物反应器和生物医药重点实验室,浙江杭州310018

出　　处：《药物生物技术》2016年第5期437-441,共5页Pharmaceutical Biotechnology

基　　金：浙江省公益技术研究社会发展项目(No.2016C33080)

摘　　要：胸腺素作为一种超家族蛋白在免疫调节、机体发育等生理活动中发挥重要作用,广泛分布于脊椎动物和无脊椎动物中,在进化过程中高度保守。对于脊椎动物胸腺素功能的研究比较清楚,已经被开发成药物应用于临床,治疗免疫缺陷性疾病、肝炎以及某些癌症。但对于无脊椎动物特别是对于家蚕等昆虫的胸腺素研究较少。在NCBI数据库中可以找到仅20种包含THY保守结构域的相关蛋白,这些蛋白分别存在于家蚕、果蝇等物种。该文就昆虫胸腺素超家族蛋白近20年来的研究进展进行了综述,包括昆虫胸腺素超家族蛋白的同源性、进化分析以及不同昆虫胸腺素的功能和特征。Thymosins,one family of thymic hormones,play an important role in physiological functions such as immune regulation and development of organisms.Thymosins widely exist in vertebrates and invertebrates.Thymosins has been highly conserved in the progress of evolution.Nowadays,the function of vertebrates thymosins has been studied thoroughly.Vertebrates thymosins have already been developed for clinical applications.Emerging evidence revealed that vertebrates thymosins were widely used as pharmacological agents in clinical practice to treat some diseases including immunodeficiency related diseases,chronic hepatitis and certain types of cancers.However,there was less research on invertebrates thymosins especially on insects,such as Bombyx mori.Only twenty related proteins composed of thymosin conservative structural domains from lepidoptera can be found in NCBI website.These proteins are highly homologous to β-thymosin（Tβ） and are distributed in Drosophila melanogaster,Bombyx mori and other species.In this paper,research progress on the homology,evolution analysis,functions and characteristics of thymosin super-family proteins from different insects in recent 20 years have been reviewed.

关 键 词：昆虫 胸腺素 同源性 进化分析 功能 进展 

分 类 号：Q963[生物学—昆虫学]