三种不同甲基强的松龙给药方法治疗突发性耳聋的临床分析  

Effects of administrating methylprednisolone in three different ways in treating sudden hearing loss

作　　者：李春林[1] 唐世雄[1] 张立涛[1] 陆徐[1] 王耀文[1] 孔德秋[1] 程鹏[1] 包卫亮 

机构地区：[1]浙江宁波市第一医院耳鼻咽喉科头颈外科 [2]宁波大学医学院

出　　处：《中国临床药理学与治疗学》2016年第11期1302-1305,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：宁波市科技计划项目(2013A610261)

摘　　要：目的:探讨应用甲基强的松龙治疗突发性耳聋的最佳给药途径。方法:将突发性耳聋患者117例分为三组,每组39例。静脉组给予静脉注射甲基强的松龙;鼓膜穿刺组给予鼓室内注射甲基强的松龙;耳后注射组给予耳后乳突区骨皮质下注射注射甲基强的松龙。结果:静脉组显效率高于鼓膜穿刺组,差异有统计学意义(P<0.05)。静脉组总有效率高于鼓膜穿刺组、耳后注射组,差异有统计学意义(P<0.05)。结论:静脉注射甲基强的松龙治疗突发性耳聋疗效可靠,总有效率稳定,可作为突发性聋激素治疗的给药方法。AIM To explore the best way of giving methylprednisolone in treating sudden hearing loss. METHODS： 117 patients with sudden hearing loss were divided into Group A （the venous group：39 patients patients were injected with me/h- ylprednisolone through vein）, Group B （the tympan- ic group： 39 patients patients were injected with methylprednisolone into tympanic cavity）, and Group C （the retroauricular group： 39 patients patients were injected with methylprednisolone subperiosteal- ly in the mastoid）. RESULTS：Group A showed significant higher markedly effective rate than Group B （ P 〈 0.05 ） ; Group A showed significant higher to- tal effective rate than Group B and C （P 〈 0.05 ）. CONCLUSION： Methylprednisolone through vein shows a higher cure rate and stable effective rate for treating sudden hearing loss,which can be used as a preliminary therapy for sudden hearing loss.

关 键 词：突发性耳聋 静脉 甲基强的松龙 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]