前列地尔治疗左室射血分数正常心力衰竭的临床观察  

Clinical Observation of Alprostadil in the Treatment of Heart Failure with Normal Left Ventricular Ejection Fraction

作　　者：宋振民[1] 蒋陆霞[1] 祁学文[2] 

机构地区：[1]聊城市人民医院药学部,山东聊城252000 [2]聊城市人民医院心内科,山东聊城252000

出　　处：《中国药房》2016年第35期4990-4992,共3页China Pharmacy

摘　　要：目的:探讨前列地尔治疗左室射血分数正常心力衰竭的临床疗效及安全性。方法:选择诊断为左室射血分数正常心力衰竭患者120例,按随机数字表法分为观察组与对照组,各60例。对照组患者给予对症治疗;观察组患者在对照组基础上给予注射用前列地尔干乳剂每次10μg,bid。两组患者均治疗5 d。观察两组患者治疗前后心功能指标、血清炎症因子、血清氧化应激指标水平,并比较不良反应发生情况。结果:治疗前,两组患者心功能指标、血清炎症因子、血清氧化应激指标水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者上述指标均显著改善,且观察组显著优于对照组,差异均有统计学意义(P<0.05)。两组患者均未见明显不良反应发生。结论:前列地尔能明显提高左室射血分数正常心力衰竭患者的心功能,改善其血清炎症因子水平及体内氧化应激水平,且安全性较好。OBJECTIVE：To investigate the clinical efficacy and safety of alprostadil in the treatment of heart failure in pa-tients with normal left ventricular ejection fraction （LVEF）. METHODS：120 patients diagnosed as heart farlture with normal LVEF were divided into observation group and control group by radom number table method,with 60 cases in each group. Control group was given symptomatic treatment;observation group was additionally treated with Alprostadil dried emulsion for injection 10μg,bid,on the basis of control group. Both groups received treatment for 5 d. The cardiac function indexes,serum inflammatory factors and oxidative stress indexes were observed in 2 groups before and after treatment,and the occurrence of ADR was com-pared between 2 groups. RESULTS：Before treatment,there was no statistical significance in cardiac function indexes,serum in-flammatory factors and oxidative stress indexes between 2 groups （P〉0.05）. After treatment,above indexes of 2 groups were all improved significantly,and the observation group was significantly better than the control group,with statistical significance（P〈0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS：Alprostadil can improve cardiac function of patients with heart failure of normal LVEF,improve serum inflammatory factors and oxidative stress level with good safety.

关 键 词：前列地尔 左室射血分数正常心力衰竭 心功能 氧化应激 炎症因子 

分 类 号：R542.51[医药卫生—心血管疾病]