围术期应用桉柠蒎肠溶软胶囊对儿童慢性分泌性中耳炎鼓膜置管术疗效和预后的影响  

Effects of Perioperative Application of ELP Enteric Soft Capsules on Therapeutic Efficacy and Prognosis in Children after Grommet Insertion of Chronic Secretory Otitis Media

作　　者：张玉峰[1] 王淑芬[1] 王智楠[1] 夏忠芳[1] 

机构地区：[1]武汉市儿童医院耳鼻喉科,武汉430000

出　　处：《中国药房》2016年第35期4995-4997,共3页China Pharmacy

摘　　要：目的：探讨围术期应用桉柠蒎肠溶软胶囊对儿童慢性分泌性中耳炎鼓膜置管术疗效和预后的影响。方法：将92例（145只患耳）慢性分泌性中耳炎患儿按随机数字表法分为观察组46例（68只患耳）和对照组46例（77只患耳）。两组患儿均行全麻耳显微镜下鼓膜置管术。对照组患儿手术前未给予任何药物治疗；观察组患儿术前3 d～术后5 d口服桉柠蒎肠溶软胶囊，每次1.2 g，bid。观察两组患儿术后3 d、5 d、2周、1个月、3个月主观疗效，纯音测听评分及术后1、3个月脱管患耳声导抗监测情况。结果：观察组患儿术后3 d、5 d、2周、1个月、3个月总有效率分别为72.06％、82.35％、85.29％、89.70％、95.59％，对照组患儿总有效率分别为59.74％、66.23％、80.52％、87.01％、92.21％，组间比较差异均有统计学意义（P＜0.05）。观察组患儿术后3 d、5 d、2周、1个月、3个月纯音测听评分显著低于对照组，差异均有统计学意义（P＜0.05）。术后1、3个月，观察组患儿脱管患耳声导抗监测有效率分别为77.78％、90.48％，显著高于对照组的61.54％、81.48％，差异均有统计学意义（P＜0.05）。结论：围术期应用桉柠蒎肠溶软胶囊能明显促进儿童慢性分泌性中耳炎鼓膜置管术后功能恢复，改善患儿听力水平。OBJECTIVE：To investigate the effects of perioperative application of Eucalyptol,limonene and pinene（ELP）en-teric soft capsules on therapeutic efficacy and prognosis in children after grommet insertion of chronic secretory otitis media. METH-ODS：92 cases（145 ears）of chronic secretory otitis media were divided into 2 groups by random number table method,including 46 cases in observation group（68 ears）and 46 cases in control group（77 ears）. Both groups received grommet insertion under gen-eral anesthesia by otomicroscope. Control group was not given any drugs;observation group was given ELP enteric soft capsules 1.2 g,bid,from 3 d before operation to 5 d after operation. Subjective therapeutic efficacy and pure tone audiometry of 2 groups were observed 3 days,5 days,2 weeks,1 month and 3 months after surgery as well as acoustic impedance monitoring in children with tube withdrawal from ear 1 month and 3 months after surgery. RESULTS：The total effective rates of observation group 3 days,5 days,2 weeks,1 month and 3 months after surgery were 72.06%,82.35%,85.29%,89.70%and 95.59%;those of con-trol group were 59.74%,66.23%,80.52%,87.01% and 92.21%,with statistical significance（P〈0.05）. The pure tone audiome-try score of observation group 3 days,5 days,2 weeks,1 month and 3 months after surgery were significantly lower than those of control group,with statistical significance（P〈0.05）. Therapeutic effective rates of acoustic impedance monitoring in children with tube withdrawal from ear 1 month and 3 months after surgery were 77.78% and 90.48% in observation group,which were signifi-cantly higher than 61.54% and 81.48% in control group,with statistical significance（P〈0.05）. CONCLUSIONS：The periopera-tive application of ELP enteric soft capsules can significantly improve function recovery and hearing level in children after grommet insertion of chronic secretory otitis media.

关 键 词：慢性分泌性中耳炎 桉柠蒎肠溶软胶囊 鼓膜置管术 疗效 预后 儿童 

分 类 号：R285.6[医药卫生—中药学]