西咪替丁固体分散体的制备及体外溶出度研究  

Preparation and in vitro dissolution of cimetidine solid dispersion

作　　者：洪亚仙 侯雪峰[2,3] 张润桐[2] 封亮[2] 贾晓斌[2] 

机构地区：[1]江苏省第二中医院,南京210017 [2]江苏省中医药研究院国家中医药管理局中药释药系统重点实验室,南京210028 [3]安徽中医药大学,合肥230012

出　　处：《中国新药杂志》2016年第23期2732-2736,共5页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(81473394)

摘　　要：目的:制备西咪替丁固体分散体,提高西咪替丁的溶出速率。方法:分别以聚乙二醇-6000(PEG-6000)、聚乙烯吡咯烷酮K-30(PVPK-30)、泊洛沙姆188为载体,用溶剂法制备西咪替丁固体分散体,采用紫外分光光度法进行含量测定,应用浆法进行体外溶出度的测定。结果:用3种载体制备的西咪替丁固体分散体均能够提高药物的溶出速率,其中以PEG-6000为载体、西咪替丁与PEG-6000质量比为1∶6时的溶出速率较佳,30 min累积溶出度达到90%。结论:固体分散体技术可以显著提高西咪替丁的溶出度,且工艺简单,易于实施。Objective： To prepare cimetidine solid dispersion for increasing the dissolution rate of cimetidine.Methods： The cimetidine solid dispersion was prepared with polyethyleneglycol-6000（ PEG-6000）,polyvinylpyrrolidone K-30（ PVPK-30） and poloxamera 188,respectively. UV spectrophotometry was used to determine the contents of cimetidine. The paddle method was used to determine the in vitro dissolution of the cimetidine solid dispersion.Results： The dissolution rate of cimetidine was enhanced for the cimetidine solid dispersion. The solid dispersion prepared with PEG-6000,in which the mass ratio of cimetidine and PEG 6000 was 1∶ 6,exhibited optimal dissolution.The cumulative dissolution was up to 90% in 40 min. Conclusion： Solid dispersion technology,which is simple and easy to implement,can significantly improve the dissolution of cimetidine.

关 键 词：西咪替丁 固体分散体 聚乙二醇-6000 溶出速率 

分 类 号：R975.6[医药卫生—药品]