眼部给药新剂型  

New Dosage Forms for Ocular Administration

作　　者：孙茹茹[1,2] 汤湛[2] 王俏[2] 

机构地区：[1]浙江工业大学药学院,杭州310014 [2]浙江省医学科学院药物研究所,杭州310013

出　　处：《中国药学杂志》2016年第23期1993-1998,共6页Chinese Pharmaceutical Journal

基　　金：浙江省医学重点学科群资助项目(XKQ-010-001);浙江省公益基金资助项目(2016C37074);浙江省医科院青年基金资助项目(2013Y002);浙江省医药卫生科技项目(2014KYB068)

摘　　要：局部眼睛用药是治疗眼部疾病最常用的方法。然而,普通制剂在眼部的生物利用度很低,这使得许多药物对眼部疾病的防治效果并不理想,也给眼部疾病治疗带来了巨大挑战。近年来,纳米制剂在眼部给药系统中得到了广泛应用。目前,几种纳米载体新剂型如聚合物胶束、纳米粒、纳米混悬剂、脂质体、乳剂和树枝状聚合物已被开发,用于眼部给药系统;还有一些其他的新剂型如原位凝胶载体系统、植入剂、隐形眼镜和微针也在不断地研究中。研发这些新剂型的最终目的都是提高药物的生物利用度及治疗效果。笔者对这些方面近年来的发展做一综述,以期为开发新型眼部给药系统提供参考。Topical ocular medication is commonly used for eye diseases treatment. In view of low bioavailability and poor efficacy of traditional ocular preparations, the development of novel ocular drug delivery systems has become a great challenge in pharmaceutics. In recent years, nano preparations have been widely used for ocular drug delivery systems. At present, several nanocarriers, such as poly- meric micelles, nanoparticles, nanosuspension, liposomes, emulsion, and dendritic polymers have been developed for ocular drug de- livery. There are some other new dosage forms, such as in-situ gelling systems, implants, contact lenses, and microneedles are also un- der continuous research. The aim of development of these new dosage forms is to improve the drugs＇ ocular bioavailability and therapeutic effects. In this paper, the development in these areas in recent years are reviewed in order to provide reference for the development of new ocular drug delivery systems.

关 键 词：眼 纳米 胶束 脂质体 原位凝胶载体系统 隐形眼镜 植入剂 微针 

分 类 号：R944[医药卫生—药剂学]