红景天苷对胰岛素抵抗HepG2细胞葡萄糖消耗量的影响  

Effect of Salidroside on glucose consumption of insulin resistance HepG2 cell in vitro

作　　者：章新晶[1] 熊爱珍[1] 

机构地区：[1]南昌大学第二附属医院药剂科,南昌330006

出　　处：《江西医药》2016年第11期1168-1169,1176,共3页Jiangxi Medical Journal

基　　金：江西省南昌市科技局课题;编号:洪财企[2012]37号

摘　　要：目的研究红景天苷(Salidroside)对胰岛素抵抗HepG2细胞葡萄糖消耗量的影响。方法采用高浓度胰岛素诱导HepG2细胞,建立体外胰岛素抵抗细胞模型,给予不同浓度的红景天苷、以胰岛素增敏剂罗格列酮为阳性对照药,以葡萄糖氧化酶法检测葡萄糖消耗量。结果与模型组比较,红景天苷组HepG2细胞葡萄糖消耗量明显增加。结论红景天苷能改善高浓度诱导的HepG2细胞胰岛素抵抗。Objective To study the effect of salidroside on glucose consumption of insulin resistance HepG2 cell. Methods High concentration insulin was added into HepG2 cells to induce insulin resistance,insulin resistant HepG2 cells model were divided into pioglitazone hydrochloridel group,different concentrational salidroside group,The glucose consumption was measured by glucose oxidase method. Results Compared with HepG2/IR group,glucose consumption in salidroside group was increased with increasing concentration.Conclusion Salidroside can improve high insulin level-induced insulin resistance in HepG2 cells.

关 键 词：红景天苷 HEPG2细胞 胰岛素抵抗 

分 类 号：R285[医药卫生—中药学]