应用钙剂和维生素D_3制剂预防儿童激素性股骨头坏死  

Prevention of steroids induced avascular necrosis in children by calcium and vitamin supplements

作　　者：邹羽真[1] 梅丹[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院药剂科,北京100730

出　　处：《中国医院药学杂志》2016年第23期2088-2091,共4页Chinese Journal of Hospital Pharmacy

摘　　要：儿童激素性股骨头坏死是由于糖皮质激素通过多途径破坏儿童股骨头的局部血供,从而引起以骨小梁和骨髓局部坏死为特征的疾病。摄入充足的钙和维生素D_3是预防本病的基础。本文介绍儿童激素性股骨头坏死的发病机制和影响因素。探索应用钙剂和维生素D_3制剂预防长期应用糖皮质激素患儿发生儿童激素性股骨头坏死的给药方案。总结文献经验,在给药时机、给药剂量和防止药物不良反应方面,提供用药参考。Steroid induced avascular necrosis of femoral head（SANFH）in children is a disease due to necrosis of bone trabecula and marrow caused by glucocorticoids,which destruct local blood supply of child＇s femoral head through diverse channels.Intake of adequate vitamin D3 and calcium is the basis to prevent this disease.This review searches data and summarizes pathogenesis and factors of SANFH,and investigates a feasible dosing regimen to prevent child SANFH by vitamin D3 and calcium supplements.The aim is to provide a reference for clinical medication at proper time and proper doses to reduce adverse effects.

关 键 词：激素性股骨头坏死 儿童股骨头坏死 缺血性坏死 钙剂 维生素D3制剂 

分 类 号：R969[医药卫生—药理学]