抑郁症组学生物标志物的研究进展  

Research progress on omics biomarkers of depression

作　　者：朱立静[1] 孙冰婷 宗阳[1] 何书芬[1] 居文政[1] 谈恒山[2] 

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]南京军区总医院,江苏南京210002

出　　处：《中国医院药学杂志》2016年第23期2131-2134,共4页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金资助项目(编号:81573685);重大新药创制(编号:2012ZX09303009-002)

摘　　要：抑郁症是一种严重的精神疾病,患病率约为15%,极大地影响了患者生活质量。然而抑郁症的发病机制尚未明确,缺乏客观的诊断方法,生物标志物可以为抑郁症的诊断及治疗提供一定的科学依据,目前公认的经典生物标志物主要包括单胺类神经递质、下丘脑-垂体-肾上腺轴因素、细胞因子、脑神经营养因子等,但存在一定的缺陷,本文主要对抑郁症组学生物标志物的研究进展进行了综述,包括基因组学,蛋白质组学,代谢组学。Depression is a serious mental illness, and the prevalence is about 15%, which greatly affects the quality of patients＇ life. However, its pathogenesis is not yet clear, and diagnosis is lack of objective check, and biomarker can provide a certain scientific basis for the diagnosis and treatment of depression. Currently, recognized classical biomarker mainly includes the monoarnine neurotransmitters, factors of the hypothalamic pituitary adrenal axis, cell factor, brain-derived neurotrophic factor and so on. This paper introduces the research progress of omics biomarkers of depression, including genomics, proteomics, metabonomics.

关 键 词：抑郁症 组学生物标志物 生物标志物 

分 类 号：R971.43[医药卫生—药品]