不同类型高血压人群血液流变学的比较研究  

Comparative Obsedvation on Hemorheology in Different Types of Hypertension

作　　者：王欢[1] 胡元会[1] 褚瑜光[1] 邱志凌[2] 薄荣强 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]中国中医科学院 [3]北京中医药大学

出　　处：《中西医结合心脑血管病杂志》2016年第22期2593-2597,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的研究不同类型高血压人群血液流变学的变化。方法选择2015年7月在中国中医科学院广安门医院南区的体检者302名,详细记录病史,测量身高、体重、体重指数(BMI)、血压等,检测血常规、生化、血液流变学等指标,应用北京赛科希德公司生产的SA-6000全自动血流变测试仪检测体检人群的血液流变学指标,并根据血压值将其分为4组,分别为健康组(n=183)、双期高血压组(n=49)、单纯舒张期高血压组(n=30)、单纯收缩期高血压组(n=40),对4组之间的血液流变学指标进行比较研究。结果经单因素方差分析检验,血液流变水平分析:双期高血压组、单纯舒张期高血压组全血低切黏度(1/s、5/s)、全血中切黏度(50/s)、全血高切黏度(100/s、200/s)、全血低切相对指数与健康组比较,差异有统计学意义(P<0.05);同时,单纯收缩期高血压组全血低切黏度(1/s、5/s)、全血中切黏度(50/s)、全血高切黏度(100/s、200/s)分别与双期高血压组、单纯舒张期高血压组比较,差异有统计学意义(P<0.05),而与健康组比较差异无统计学意义。单纯收缩期高血压组全血高切相对指数与双期高血压组比较,差异有统计学意义(P<0.05)。而4组之间血浆黏度与红细胞聚集指数比较差异无统计学意义。血脂水平:双期高血压组、单纯舒张期高血压组、单纯收缩期高血压组三酰甘油(TG)、总胆固醇(TC)与健康组比较,差异有统计学意义(P<0.05),单纯收缩期高血压组三酰甘油、低密度脂蛋白胆固醇(LDL-C)与双期高血压组比较,差异有统计学意义(P<0.05)。偏相关性分析:TG、TC、高密度脂蛋白胆固醇(HDL-C)与全血高切相对指数呈正相关性(r=0.180,P=0.006;r=0.275,P=0.000;r=0.170,P=0.009)。结论在高血压发展过程中,单纯舒张期高血压、双期高血压均存在明显的血液黏滞状态,而单纯收缩期高血压有血液黏滞趋势,但血液黏滞状态不明显。舒张压是高血�Objective To study blood rheology changes about the different types of hypertension. Methods Three hundreds and two patients in the medical center of the Southern District of Guanganmen Hospital of China Academy of Chinese Medical Sciences in July 2015 were selected. Asking medical history,measuring height,weight,BMI,blood pressure,blood routine and biochemical indicators,blood rheology and other indicators,and applying SA-6000 automatic blood hemorheology test detecting medical groups,and based on the blood pressure value,all were divided into four groups,namely health group（n = 183）,double hypertensive group（n = 49）,isolated diastolic hypertension group（n = 30）,isolated systolic hypertension group（n = 40）. The blood rheology were compared among four groups. Results ANOVA test showed that whole bloodlow cut（1 / s,5 / s）,whole blood cut（50 / s）,whole blood high cut（100 / s,200 / s）,whole blood low cutrelative index of hypertension group and IDH group were statistically higher than health group（P〈0. 05）. The low blood cut（1 / s,5 / s）,whole blood cut（50 / s）,high shear whole blood（100 / s,200 / s） of isolated systolic hypertension were respectively lower than hypertensive group and isolated diastolic hypertension group（P〈0. 05）,whereas there was no significant difference between the healthy group. Whole blood high cut relative index of isolated systolic hypertension was statistically lower than hypertensive group（P〈0. 05）. There was no difference between plasma viscosity and erythrocyte aggregation index. Analysis of lipid levels showed that triglycerides and cholesterol level of hypertension,isolated diastolic hypertension and isolated systolic hypertension were statistically higher than health groups（P〈0. 05）,there was statistically significant difference between isolated systolic hypertension and hypertensive group on level of the triglycerides and low density lipoprotein（P〈0. 05）. Correlation analysis showed that triglycerides（ TG）,chole

关 键 词：高血压 单纯舒张期高血压 单纯收缩期高血压 血液流变学 

分 类 号：R544.1[医药卫生—心血管疾病]