降钙素原在脓毒症病情评估和预后判断中的应用价值  

作　　者：李彦嫦[1] 

机构地区：[1]广西科技大学第一附属医院重症医学科,545002

出　　处：《湖南中医药大学学报》2016年第A02期1424-1425,共2页Journal of Hunan University of Chinese Medicine

摘　　要：目的：分析脓毒症病情评估与预后判断中降钙素原的应用价值.方法：选择本院ICU病房2014年6月～2016年6月治疗的脓毒症患者73例,依照脓毒症病情严重程度,分为早期组、严重组、休克组,给予其降钙素原（PCT）、C反应蛋白（CRP）检测,并评估急性生理与慢性健康状况评分（APACHEⅡ）;同时,按照不同PCT水平,分为〈5.0ng/mL 组、5.0～10.0ng/mL 组、〉10.0ng/mL 组,观察其死亡率、住院时间.结果：早期组 PCT、CRP、APACHE Ⅱ评分均低于严重组及休克组,且严重组低于休克组,差异具有统计学意义（P〈0.05）;PCT〈5.0ng/mL组死亡率、住院时间低于5.0～10.0ng/mL组、〉10.0ng/mL组,且5.0～10.0ng/mL组低于〉10.0ng/mL组,差异具有统计学意义（P〈0.05）.结论：临床评估脓毒症患者病情严重程度及判断患者预后情况时,降钙素原具有比较高的应用价值,可提升评估与判断的准确性,从而合理调整治疗方案,降低病死率.Objective： To evaluate the value of procalcitonin in assessing the prognosis of sepsis. Methods： Seventy-three patients with sepsis who were treated from June, 2014 to June, 2016 in our hospital were divided into early group, severe group and shock group according to sepsis severity. （PCT） and C-reactive protein （CRP）, and to evaluate acute physiology and chronic health status （APACHE Ⅱ）. According to different PCT levels, the patients were divided into 5.0ng / mL group, 5.0-10.0ng / 10.0ng / mL group. The mortality and hospitalization time were observed. Results： The PCT, CRP and APACHE Ⅱ scores of the early group were lower than those of the severe group and the shock group, and the difference was statistically significant （P 〈0.05）. The death rate, hospitalization time （10.0 ng / mL） and 5.0 ng / mL to 10.0 ng / mL. The difference was statistically significant （P 〈0.05）. Conclusion： The clinical application of procalcitonin in assessing the severity of sepsis and predicting the prognosis of patients with sepsis can improve the accuracy of assessment and judgment, and adjust the treatment regimen to reduce the mortality.

关 键 词：降钙素原 脓毒症 病情评估 预后判断 

分 类 号：R2[医药卫生—中医学]