大剂量甲基强的松龙冲击疗法对急性百枯草中毒患者血清同工酶及炎症因子水平的影响  

Effects of serum isoenzyme and inflammatory factors by large doses of methyl prednisolone shock therapy in the treatment of patients with acute hundred withered grass poisoned

作　　者：徐少博[1] 刘雪兰[1] 

机构地区：[1]浙江省宁波市医疗中心李惠利医院急诊病房,浙江宁波315040

出　　处：《中国生化药物杂志》2016年第11期127-130,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的研究大剂量甲基强的松龙冲击疗法对急性百枯草中毒患者血清同工酶及炎症因子水平的影响。方法选取2014年6月-2015年10月浙江省宁波市医疗中心李惠利医院急诊内科收治46例急性百枯草中毒患者,随机分成2组,各23例。在常规治疗基础上,对照组予血液灌流治疗,观察组在对照组基础上再予大剂量甲基强的松龙冲击疗法,观察比较治疗前后血清有关酶及炎症因子水平,观察临床症状、治疗效果及不良反应。结果与治疗前比较,2组IL-1、IL-10、TNF-α以及CRP水平降低（P〈0.05）,CK、CK-MB、TGF-β1及HIF-1α水平降低（P〈0.05）;与对照组比较,观察组IL-1、IL-10、TNF-α及CRP水平较低（P〈0.05）,CK、CK-MB、TGF-β1以及HIF-1α水平较低（P〈0.05）,治疗后距最后一次排绿色便的时间、血浆PQ清除时间以及住院时间较短（P〈0.05）,治疗总有效率较高（P〈0.05）。结论大剂量甲基强的松龙冲击疗法对急性百枯草中毒患者疗效确切,能够降低患者血清CK、CK-MB、TGF-β1、HIF-1α以及炎症因子水平,安全性较高。Objective To investigate the effects of serum isoenzyme and inflammatory factors by large doses of methyl prednisolone shocktherapy in the treatment of patients with acute hundred withered grass poisoned. Methods 46 cases of patients with acute hundred withered grass poisoned from June 2014 to October 2015 in ningbo medical center lihuili hospital were collected and randomly divided into two groups,23 cases in each group. On the base of the conventional treatment,patients in the control group were treated by blood perfusion therapy,patients in the experiment group were treated with large dose of methyl prednisolone shock therapy on the base of the control group,tested and compared the levels of serum enzyme and inflammatory factors before and after treatment,observed the clinical symptoms,clinical efficacy and adverse reactions. Results Compared with before treatment,the levels of IL-1,IL-10,TNF-α and CRP in two groups were decreased（ P〈0. 05）,levels of CK,CK-MB,TGF-β1 and HIF-1α decreased（ P〈0. 05）; Compared with the control group,the levels of IL-1,IL-10,TNF-α and CRP in the experiment group were lower（ P〈0. 05）; CK,CK-MB,TGF-β1 and HIF-1αlevels were lower（ P〈0. 05）,after treatment from the last row of green time,the plasma PQ clearance time and length of hospital stay were shorter（ P〈0. 05）,total effective rate was higher（ P〈0. 05）. Conclusion Large doses of methyl prednisolone shock therapy in the treatment of patients with acute hundred withered grass poisone has definite clinical efficacy,can reduce the patients＇ serum CK,CK-MB,TGF-β1,HIF-1α and inflammatory factors levels,with higher security.

关 键 词：急性百枯草中毒 甲基强的松龙 同工酶 炎症因子 

分 类 号：R595.4[医药卫生—内科学]