注射用丹参多酚酸盐联合胶原蛋白海绵治疗糖尿病足的效果评价  

Effects of salvia miltiorrhiza polyphenols for injection and collagen sponge in diabetic foot

作　　者：姚卫杰[1] 王鹏华[1] 徐俊[1] 李雪梅[1] 丁敏[1] 

机构地区：[1]天津医科大学代谢病医院糖尿病足科,内分泌研究所,卫生部激素与发育重点实验室,天津市代谢性疾病重点实验室,天津300070

出　　处：《中国生化药物杂志》2016年第11期131-133,137,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨注射用丹参多酚酸盐联合胶原蛋白海绵治疗糖尿病足的效果。方法选择天津医科大学代谢病医院2型糖尿病糖尿病足患者115例,随机分为治疗组55例以及常规治疗对照组60例。治疗组给予常规治疗加2型糖尿病治疗加注射用丹参多酚酸盐联合胶原蛋白海绵;每个疗程4周,观察8周,收集治疗前后及治疗期间溃疡等情况和不良反应情况。结果治疗4周后,治疗组足溃疡面积减少30%及以上的病例数为17例(30.91%),治疗6周后足溃疡面积减少30%及以上的病例数为33例(60.00%),治疗8周后为49例(89.09%);对照组4、6、8周后足溃疡面积减少30%及以上的病例数及所占比例分别为12(20.00%),22(36.67%)和39(65.00%);3个时间点2组足溃疡愈合情况未见统计学差异;随访8周,治疗组治愈率为38.18%,高于对照组的20.00%(P<0.001);治疗有效率2组分别为50.91%和45.00%,未见统计学差异;治疗组总有效率显著高于对照组(89.09%vs.65.00%)(P<0.001);同时,对照组无效率高于治疗组(P<0.05)。结论注射用丹参多酚酸盐联合胶原蛋白海绵对糖尿病足的治疗效果明显,特别是在提高治愈率方面,明显高于常规治疗。Objective To investigate the effect of polyphenol of salvia miltiorrhiza polyphenols combined with collagen sponge in the treatment of diabetic foot. Methods A total of 115 patients with type 2 diabetic foot were randomly divided into treatment group（ 55 cases） and control group（ 60cases）. Salvia miltiorrhiza polyphenols and collagen sponge treatment group were treated with conventional treatment plus type 2 diabetes treatment of salvia miltiorrhiza polyphenol combined with collagen sponge; 4 weeks as a treatment course,observation of 8 weeks,ulcer and other adverse reactions were recorded and compared. Results After 4 weeks of treatment,17 cases（ 30. 91%） with 30% or more reduction in foot ulcer area in treatment group,33 cases（ 60. 00%） after 6 weeks treatment and the number of cases with 30% or more reduction in foot ulcer area,49 cases（ 89. 09%） after 8weeks of treatment,and the number of cases and the proportion of cases with 30% or more decrease of ulcer area in the control group after 4,6 and 8weeks were 12（ 20. 00%）,22（ 36. 67%） and 39（ 65. 00%）. There was no statistical difference between the two groups for the healing time of foot ulcer at three time points. After 8 weeks of treatment,the cure rate was 38. 18% in salvia miltiorrhiza polyphenol combined with collagen sponge group.The effective rate was 50. 91% and 45. 00% for the two groups,the difference was not statistically significant; while the total effective rate was also significantly higher（ 89. 09% vs. 65. 00%,P〈0. 01）. Conclusion Salvia miltiorrhiza polyphenol combined with collagen sponge has a good effect on diabetic foot treatment,especially it can improve the cure rate,which is superior to the routine therapy.

关 键 词：注射用丹参多酚酸盐 胶原蛋白海绵 糖尿病足 疗效评价 

分 类 号：R587.2[医药卫生—内分泌]