阿司匹林对斑马鱼胃肠道的毒性研究  

Toxicity of aspirin to gastrointestinal tract of zebrafish

作　　者：孙晨[1] 何秋霞[1] 韩利文[1] 陈锡强[1] 王希敏[1] 楚杰[1] 韩建[1] 王荣春[1] 侯海荣[1] 刘可春[1] SUN Chen HE Qiu-xia HANLi-wen CHEN Xi-qiang WANG Xi-min CHU Jie HAN Jian WANG Rong -chun HOU Hai- rong LIU Ke-chun(Key Laboratory for Drug Screening Technology of Shandong Academy of Sciences,Biology Inst i tute,Shandong Academy of Science s ,Jinan 250014,China)

机构地区：[1]山东省科学院药物筛选技术重点实验室,山东省科学院生物研究所,山东济南250014

出　　处：《山东科学》2016年第6期50-55,共6页Shandong Science

基　　金：山东省自主创新重大专项(2014ZZCX0214);山东省三院联合基金(ZR2015YL009);山东省科学院青年基金(2015QN011)

摘　　要：以斑马鱼作为动物模型,通过胃肠道蠕动功能分析、胃肠道内皮细胞分泌功能检测和肠粘膜组织形态学观察等,对阿司匹林的胃肠道毒性做了初步分析。研究发现,阿司匹林浓度为50μg/m L时,可以加快斑马鱼胃肠道的蠕动;浓度为50μg/m L或100μg/m L时,虽然斑马鱼肠粘膜的组织形态未受损害,但是位于肠粘膜上的杯状细胞的分泌功能会受到影响。We performed a preliminary analysis of gastrointestinal toxicity of aspirin through analysis of peristalsis,detection of secretion functionality of gastrointestinal endothelial cells and histomorphology of intestinal mucosa with zebrafish as animal model. We discover that aspirin concentration of 50 μg/mL can improve the peristalsis. Aspirin concentration of 50 μg/mL or 100 μg/mL will impair secretion functionality of goblet cells on intestinal mucosa though routine HE staining among intestinal mucosa does not change.

关 键 词：阿司匹林 斑马鱼 胃肠道 毒性 

分 类 号：R965.3[医药卫生—药理学]