血清CRP与PCT在糖尿病足感染病情严重程度及预后评估价值研究  

Value of serum CRP and PCT in assessment of severity and prognosis of diabetic foot infection

作　　者：金剑虹[1] 洪郁芝[1] 徐新鹏[1] 杨晓春[1] 朱岚[1] 

机构地区：[1]浙江中医药大学附属广兴医院内分泌代谢科,浙江杭州310007

出　　处：《中华医院感染学杂志》2016年第24期5616-5618,共3页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅基金管理项目(2012KYA155)

摘　　要：目的探讨血清C-反应蛋白(CRP)和降钙素原(PCT)在糖尿病足感染病情严重程度及预后评估中的价值,为临床治疗提供参考依据。方法选择医院2014年1月-2015年12月住院糖尿病足感染患者177例作为研究对象,根据感染程度将其分为A组(轻度感染组)48例、B组(中度感染组)99例、C组(重度感染组)30例,根据糖尿病足治疗效果分为治愈组、好转组及无效组;测定各组患者血清CRP和PCT水平。结果 A组血清CRP和PCT水平低于B组和C组(P<0.05),B组血清CRP和PCT水平低于C组(P<0.05);3组治疗后血清CRP和PCT水平均较治疗前显著降低(P<0.05);治疗后,治愈组血清CRP和PCT水平低于好转组和无效组(P<0.05),好转组血清CRP和PCT水平低于无效组(P<0.05)。结论血清CRP和PCT水平随着糖尿病足感染严重程度的增加而升高,随着病情的好转而逐渐下降,血清CRP和PCT在糖尿病足感染严重程度和预后评估中具有一定的临床价值。OBJECTIVE To explore the value of serum C-reactive protein（CRP）and procalcitonin（PCT）in assessment of severity and prognosis of diabetic foot infection so as to provide guidance for clinical treatment.METHODS A total of 177 patients with diabetic foot infection who were treated in the hospital from Jan 2014 to Dec 2015 were recruited as the study objects and divided into the group A（the mild infection group）wit 48 cases,the group B（the moderate infection group）with 99 cases,and the group C（the severe infection group）with 30 cases according to the severity of the infection;the enrolled patients were divided into the cured group,the improved group,and the ineffective group according to the curative effect of diabetic foot.The levels of serum CRP and PCT were determined.RESULTS The levels of serum CRP and PCT were lower in the group A than in the group B and the group C（P〈0.05）;the levels of serum CRP and PCT were lower in the group B than in the group C（P〈0.05）;the levels of serum CRP and PCT of the three groups were remarkably lower after the treatment than before the treatment（P〈0.05）.The levels of serum CRP and PCT were lower in the cured group than in the improved group and the ineffective group after the treatment（P〈0.05）;the levels of serum CRP and PCT were lower in the improved group than in the ineffective group（P〈0.05）.CONCLUSIONThe levels of serum CRP and PCT are elevated with the increase of severity of diabetic foot infection and decline with the improvement of illness condition.The serum CRP and PCT have certain clinical value in assessment of severity and prognosis of the diabetic foot infection.

关 键 词：糖尿病足 感染 C-反应蛋白 降钙素原 

分 类 号：R587[医药卫生—内分泌]