聊城市HPV感染状况及亚型分析  

HPV infection situation and genetic subtype analysis in Liaocheng

作　　者：郑丽丽[1] 郑丽媛[2] 杨亚培[1] 李玉红[3] 王伟华[1] 

机构地区：[1]聊城市人民医院中心实验室,山东聊城252000 [2]山东大学微生物技术国家重点实验室,山东济南250000 [3]聊城市人民医院病理科,山东聊城252000

出　　处：《中华医院感染学杂志》2016年第24期5683-5685,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨不同年龄段女性HPV易感性,并分析不同HPV亚型在聊城地区的分布特点及致宫颈上皮内瘤变作用差异。方法选取2014年8月-2015年12月医院因宫颈疾病就诊3 095例患者,进行过HPV分型检测,对阳性患者进行宫颈细胞学检查或阴道镜活检,数据采用SPSS 17.0软件进行统计分析。结果 HPV阳性患者830例,占26.82%;以30-49岁年龄段HPV感染为主,占31.20%;宫颈高级别病变患者中检出最多的HPV亚型前三位分别是HPV16、59、58;≥2种HPV亚型混合感染在宫颈高级别和低级别病变组与正常对照组间差别有统计学意义（P〈0.05）。结论 30-49岁年龄段HPV感染比例最高,宫颈上皮内瘤变比例随年龄及混合感染增高而增高;聊城市引起宫颈高级别上皮内瘤变的HPV亚型为HPV16、59、58。OBJECTIVE To explore the HPV susceptibility of women in different age groups,and investigate the distribution of HPV genetic subtype in Liaocheng and the effect of HPV on cervical intraepithelial neoplasia.METHODS A total of 3095 women examined in Liaocheng People′s Hospital because of the cervical diseases from Aug.2014 to Dec.2015 were included in the study.The HPV genotyping was detected in all of them.The cervical cytology or colposcopy biopsy was carried in positive patients.The data were analyzed by SPSS 17.0.RESULTS Totally 830 HPV positive patients were detected in 3095 women,with the positive rate of 26.82%.The incidence of HPV infection was relative higher in women aged 30~49years old,accounting for 31.20%.High-grade cervical intraepithelial lesions were mainly caused by HPV16,59,and 58.Two or more HPV genetic subtypes mixed infections in deferent groups（HSIL,LSIL and NILM）were significant difference（P〈0.05）.CONCLUSION The highest percentage of HPV infection is in patients aged 30 to 49years old.Cervical intraepithelial neoplasia ratio increased with age and subtype mixed infection.HPV genetic subtypes causing high-grade intraepithelial neoplasia in Liaocheng are HPV16,59,58.

关 键 词：人乳头状瘤病毒 基因分型 宫颈上皮内瘤变 

分 类 号：R373[医药卫生—病原生物学]