胆囊结石的相关危险因素分析  

Analysis of Influence Factors of Gallstone

作　　者：刘清[1] 金俊哲[1] 吕洪洋 邢保健 

机构地区：[1]中国医科大学附属第四医院普外科,辽宁沈阳110032

出　　处：《中国普外基础与临床杂志》2016年第12期1492-1495,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨胆囊结石的影响因素。方法回顾性分析2015年4月至2016年4月期间在笔者所在医院普外科住院的511例患者的临床资料,探讨胆囊结石的影响因素。结果 511例患者中,胆囊结石274例(胆囊结石组),无胆囊结石237例(对照组)。单因素分析结果表明,胆囊结石组与对照组的年龄、性别构成及合并糖尿病情况比较差异均无统计学意义(P>0.050),胆囊结石组的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)及空腹血糖(FBG)水平均高于对照组(P<0.050),而高密度脂蛋白(HDL-C)水平低于对照组(P=0.001)。多因素logistic回归分析结果表明,经控制混杂因素后,合并糖尿病〔OR=4.491;95%CI为(2.021,9.976);P<0.001〕、TC水平〔OR=2.548;95%CI为(1.944,3.338);P<0.001〕、HDL-C水平〔OR=0.115;95%CI为(0.056,0.237);P<0.001〕及FBG水平〔OR=1.277;95%CI为(1.086,1.502);P=0.003〕均是胆囊结石的影响因素,合并糖尿病者的胆囊结石的发生率高于未合并糖尿病者;TC和FBG水平越高,胆囊结石的发生率越高;HDL-C水平越高,胆囊结石的发生率越低。结论高TC和FBG水平、低HDL-C水平及合并糖尿病均是胆囊结石的危险因素。Objective To explore the influence factors of gallstone. Methods Clinical data of 511 patients who were admitted to our hospital from Apr. 2015 to Apr. 2016 were retrospectively analyzed. Results Of 511 patients, there were 274 patients with gallstone （gallstone group） and 237 patients without gallstone （control group）. Univariate analysis results showed that, no significant difference of age, gender, and diabetes was found between gallstone group and control group （P〉0.050）, but the levels of serum total cholesterol （TC）, triglyceride （TG）, low density lipoprotein （LDL-C）, and fasting blood glucose （FBG） were significantly higher in patients of gallstone group （P〈0.050）, but the level of serum high density lipoprotein （HDL-C） was significantly lower in patients of gallstone group （P=0.001）. Logistic regression results showed that four factors including diabetes [ OR=4.491; 95% CI is （2.021, 9.976）; P〈0.001 ], the serum TC [ OR=2.548; 95% CI is （ 1.944, 3.338）; P〈0.001 ], HDL-C [ OR=0. 115; 95% CI is （0.056, 0.237）; P〈0.001 ], and FBG [ OR= 1.277; 95% CI is （1.086, 1.502）; P=0.003 ] entered the final regression model after controlling confounding factors. The results showed that patients who combined with diabetes, high levels of serum TC and FBG, and low level of serum HDL-C, had higher ratio of galls- tone. Conclusion Diabetes, high-level of serum TC and FBG, low-level of serum HDL-C were risk factors of gallstone.

关 键 词：胆囊结石 影响因素 血脂 空腹血糖 性别 年龄 糖尿病 

分 类 号：R657.4[医药卫生—外科学]