小梁切除术联合丝裂霉素C与羊膜植入对犬青光眼的治疗试验  

Efficacy of Trabeculectomy with Mitomycin C and Amniotic Membrane Implantation for Canine Glaucoma

作　　者：董俊[1] 王少伟[1] 宋鸽[1] 丁明星[1] 

机构地区：[1]华中农业大学动物医学院,湖北武汉430070

出　　处：《动物医学进展》2016年第12期55-59,共5页Progress In Veterinary Medicine

基　　金：武汉亚洲心脏病医院合作基金项目(720107-3147142)

摘　　要：探讨丝裂霉素C和羊膜植入在犬青光眼小梁切除术中的临床效果。成功建立12只(24只眼)犬的青光眼模型,随机分为4组(每组6只眼,每只犬双眼行不同手术),即单纯小梁切除组(CT组),行普通小梁切除术;丝裂霉素C组(MMC组),行小梁切除术联用丝裂霉素C;羊膜组(AM组),行小梁切除术联用羊膜植入;羊膜联合丝裂霉素C组(AM+MMC组),行小梁切除术联用丝裂霉素C和羊膜植入。以术后眼压、滤过泡、并发症及纤维组织增生为指标,评价青光眼的治疗效果。结果显示,小梁切除术联用丝裂霉素C和羊膜植入在降低眼压、提高滤过功能、减少并发症和瘢痕形成等方面的效果优于其他组。To probe into the efficacy of trabeculectomy with mitomycin C and amniotic membrane implanta- tion for canine glaucoma,the models of glaucoma in 24 eyes of 12 dogs were successfully established. Dogs with artificially induced glaucoma were randomly divided into 4 treatment groups： common trabeculectomy （CT group）, trabeculectomy combined with mitomycin C （MMC group）, trabeculectomy combined with amniotic membrane （AM group）,and trabeculectomy combined with mitomycin C and amniotic membrane （AM ＋ MMC group） ,6 eyes per each treatment,and each dog in two eyes was asked to use different surgical methods. The postoperative intraocular pressure, filtering bleb,complication and fibrous tissue proliferation were taken as indexes to evaluate the treatment efficacy of glaucoma. The results showed that trabeculectomy with mitomycin C and amniotic membrane implantation was better than other groups in reducing the intraocular pressure, maintaining the function bleb long time, decreasing scarring and complication.

关 键 词：犬青光眼 小梁切除 丝裂霉素C 羊膜 

分 类 号：S853.56[农业科学—临床兽医学]