重度宫腔粘连患者发病的相关因素研究  

Application value of progesterone vaginal sustained-release gel in luteal support of hormone replacement-frozen embryo transfer

作　　者：陈慧娟[1] 王浩[1] 俞佳丽 

机构地区：[1]义乌市中心医院妇科,浙江义乌322000

出　　处：《中国妇幼保健》2016年第24期5359-5360,共2页Maternal and Child Health Care of China

摘　　要：目的探讨重度宫腔粘连患者发病的相关因素。方法回顾性分析112例宫腔粘连患者的临床资料,分析重度宫腔粘连患者发病的相关因素。结果 112例宫腔粘连患者中81例(72.31%)患者为轻、中度宫腔粘连,31例(27.69%)患者为重度宫腔粘连。吸宫时负压高、吸宫时间长、病因、既往宫腔操作次数多、二次清宫、前次宫腔操作与粘连分离术间隔时间短是重度宫腔粘连患者发病的独立危险因素(P<0.05)。结论吸宫时负压高、吸宫时间长、病因、既往宫腔操作次数多、二次清宫、前次宫腔操作与粘连分离术间隔时间短是重度宫腔粘连患者发病的危险因素,对于此类患者应当加强监控,做到早发现、早治疗。Objective To compare the effects of luteal support using different progesterone preparations after frozen embryo transfer（FET） in hormone replacement cycles and natural cycles on pregnancy outcomes,research the clinical application value of progesterone vaginal sustained- release gel（ Crinone）. Methods A total of 252 hormone replacement FET cycles and 295 natural FET cycles were analyzed retrospectively in the center from January 2013 to December 2014. The patients were divided into group A（ intramuscular injection of progesterone and oral administration of dydrogesterone） and group B（ intramuscular injection of progesterone and Crinone） according to different luteal support options. The clinical pregnancy rates,ongoing pregnancy rates,and implantation rates in the two groups were compared.Results In hormone replacement cycles,the biochemical pregnancy rate and clinical pregnancy rate in group B were 66. 67% and58. 33%,respectively,which were statistically significantly higher than those in group A（55. 22% and 41. 11%）（ P〈0. 05）. In natural cycles,there was no statistically significant difference in biochemical pregnancy rate,clinical pregnancy rate,and implantation rate between group A and group B（ P〈0. 05）. Conclusion Progesterone vaginal sustained- release gel can improve clinical pregnancy rate used in hormone replacement FET cycles without endogenous progesterone.

关 键 词：宫腔粘连 重度 发病 相关因素 

分 类 号：R711.74[医药卫生—妇产科学]