辛伐他汀对2型糖尿病患者血管脆性的影响  

Effect of simvastatin on blood vessel brittleness in patients with type 2 diabetes mellitus

作　　者：龚世富 吴冀川[2] 毛继 刘俊强 黄谦 余中国 王资安 田祝平 

机构地区：[1]安岳县第三人民医院内分泌科,四川资阳642350 [2]四川省医学科学院.四川省人民医院内分泌科,成都610000

出　　处：《重庆医学》2016年第35期4995-4997,共3页Chongqing medicine

摘　　要：目的探讨辛伐他汀对2型糖尿病(T2DM)患者血管脆性的影响。方法选取2013年10月至2014年3月于安岳县第三人民医院就诊的T2DM患者95例,将其分为观察组(50例,其中2例退出研究)与对照组(45例),均采用联合口服药物或胰岛素强化治疗,将试验开始前1个月内患者血糖和糖化血红蛋白(HbA1c)水平控制在空腹血糖小于或等于7.0 mmol/L、HbA1c≤7.0%,并维持在该水平。观察组在此基础上每晚加服辛伐他汀40mg,观察12个月。测定干预前后血三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白(CRP)水平和颈动脉内膜中膜厚度(IMT)。结果观察组与对照组干预后空腹血糖、HbA1c、CRP、TG及LDL-C水平与干预前比较,差异均有统计学意义(均P=0.000)。观察组干预前后IMT比较,差异有统计学意义(P=0.002);而对照组干预前后IMT比较,差异无统计学意义(P=0.910)。两组干预后空腹血糖和HbA1c水平比较,差异均无统计学意义(P值分别为0.851、0.646);其余各项指标均观察组低于对照组,差异均有统计学意义(P=0.000)。结论T2DM患者在无他汀类药物禁忌证的情况下,长期口服他汀类降脂药物对防治动脉粥样硬化及降低血管脆性具有积极作用。Objective To explore the effect of simvastatin on blood vessel brittleness in patients with type 2 diabetes mellitus （T2DM）. Methods A total of 95 cases of patients with T2DM treated in the Third People＇s Hospital of Anyue County were selected and divided into observation group（50 cases,2 cases of patients were exclused） and control group（45 cases）. The two groups adopted combined oral medications or insulin intensive therapy to controlling blood glucose（≤7.0 retool/L） and H bAlc（≤7.0 %） 1 month before intervention,and maintained fasting blood glucose and HbAlc on this level. Additionally, the observation group received 40 mg simvastatin one night, which lasted for 12 months. The levels of blood TG, LDL-C,CRP and common carotid artery intima-media thickness（IMT） were determined before and after intervention. Results There were statistically significant differences in levels of fasting blood-glucose,TG,LDL-C and CRP in the observation group and control group between before intervention and after intervention（P=0. 000）. In the observation group, statistically significant difference was found in the IMT before and after in- tervention （P = 0. 002）, while no obvious difference was found in the control group（P = 0.910）. After intervention, there was no statistically significant difference in fasting blood-glucose and HbAlc between the observation group and control group（P = 0. 851, 0. 646）,while statistically significant differences were found in the levels of TG, LDL-C, CRP and IMT between the two groups （P=0. 000）. Conclusion For patients with T2DM in the absence of statins-related contraindications,long-term application of lipid-lowering drugs,oral statins, plays a positive role in the prevention and treatment of atherosclerosis, and reducing blood vessel brittleness.

关 键 词：辛伐他汀 糖尿病 2型 血管脆性 

分 类 号：R587.2[医药卫生—内分泌]