碳量子点标记的硼替佐米缓释制剂的合成与应用  

Synthesis and application of the carbon quantum dot-labeled bortezomib release agent

作　　者：王兵[1,2,3] 孙捷[1,2,3] 王晓静[1,2,3] 孙敬勇[1,2,3] 李娜[1,2,3] 

机构地区：[1]济南大学山东省医学科学院医学与生命科学学院,山东济南250062 [2]山东省医学科学院药物研究所,山东济南250062 [3]山东省罕少见病重点实验室,山东济南250062

出　　处：《化学研究》2016年第6期733-736,共4页Chemical Research

基　　金：山东省自然科学基金(ZR2015YL041)

摘　　要：硼替佐米的肽硼酸与壳聚糖的羟基发生酯化反应生成肽硼酸酯,即得到硼替佐米-壳聚糖复合物;然后,该复合物中壳聚糖的氨基与碳量子点表面羧基发生静电吸附作用,将碳量子点吸附进入壳聚糖体系内,进而得到硼替佐米-壳聚糖-碳量子点复合纳米粒载体.此产物具有生物相容性、无毒副作用、荧光示踪及pH敏感等性质,在生物传感、生物医用材料、功能纳米材料,尤其是药物载体或制剂的控制释放方面,具有重要的研究意义和应用价值.A bortezomib-chitosan complex was synthesized based on the esterification reaction between bortezomib peptide boronic acid and hydroxyl groups of chitosan;the carbon quantum dot enters the chitosan system through the electrostatic adsorption of the chitosan amino of bortezomib-chitosan complex and carboxyl of carbon quantum dot＇s surface to get bortezomibchitosan-carbon composite quantum dot nanoparticle carrier.This product has the nature of biocompatibility,non-toxic side effects,fluorescent tracer and pH sensitive.This product has important significance and application value in biosensors,biomaterials,functional nanomaterials,especially in terms of drug delivery and controlled release of drug formulation.

关 键 词：碳量子点 硼替佐米 缓释制剂 壳聚糖 

分 类 号：O62[理学—有机化学]