血清视黄醇结合蛋白4和性激素水平与子宫内膜增生的相关性研究  

Correlation of serum retinol-binding protein 4,sex hormone levels and endometrial hyperplasia

作　　者：樊李平[1] 李晓红[1] 易红[1] 李慧[1] 

机构地区：[1]暨南大学附属深圳市宝安区妇幼保健院生殖健康科,广东518101

出　　处：《中华妇幼临床医学杂志（电子版）》2016年第6期731-734,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：深圳市宝安区科技计划项目(2015109)~~

摘　　要：目的 探讨血清视黄醇结合蛋白（RBP）4和性激素水平与子宫内膜增生（EH）的相关性。方法 选取2016年1月至6月,在暨南大学附属深圳市宝安区妇幼保健院生殖健康科就诊并经病理学检查诊断为EH的80例患者为研究对象。按照病理学检查结果,将其分为A组（n=60,单纯性EH和复杂性EH）,B组（n=20,非典型EH）。采用阴道二维彩色多普勒超声测定患者体内子宫内膜厚度;采用化学发光法测定卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇、泌乳素、睾酮、脱氢表雄酮（DHEA）水平,并采用酶联免疫吸附（ELISA）法检测血清RBP4水平。对2组患者的血清RBP4、FSH、LH、雌二醇、睾酮、DHEA水平共计6项因素,采用多因素非条件logistic回归分析法,对导致EH的危险因素进行分析。2组患者年龄、人体质量指数、月经周期、孕次、糖尿病史构成比、高血压史构成比等一般临床资料比较,差异均无统计学意义（P〉0.05）。本研究遵循的程序符合暨南大学附属深圳市宝安区妇幼保健院人体试验委员会制定的伦理学标准,得到该委员会批准,分组征得受试者的知情同意,并签署临床研究知情同意书。结果 ① A组患者血清RBP4、雌二醇、睾酮、DHEA水平均低于B组,且差异均有统计学意义（P〈0.05）;而2组患者FSH、LH水平比较,差异均无统计学意义（P〉0.05）。②多因素非条件logistic回归分析结果显示,血清RBP4水平（OR=1.564,95%CI：7.655-16.540,P=0.006）及睾酮水平（OR=1.652,95%CI：1.689-4.156,P=0.036）,可能与EH患者子宫内膜厚度有关。结论 血清RBP4、雌二醇、睾酮、DHEA水平可能与EH恶性病变有关,血清RBP4及睾酮水平与EH患者子宫内膜厚度有密切关系。Objective To explore correlations between serum retinol-binding protein （RBP）4, sex hormone levels and endometrial hyperplasia （EH）. Methods A total of 80 cases of EH were admitted into Shenzhen Baoan District Maternity ＆ Child Heathcare Hospital from January to June, 2016. According to the results of pathological examination, they were divided into group A （n= 60, patients with simple EH or complex EH） and group B （n= 20, patients with atypical EH）. The endometrial thickness of patients was detected by transvaginal color Doppler ultrasound. The levels of follicle stimulating hormone （ FSH ）, luteinizing hormone （ LH ）, estradiol, testosterone, dehydroepiandrosterone dehydroepiandrosterone （DHEA） and RBP4 expression levels were detected by chemiluminescence and enzyme linked immunosorbent assay （ELISA） method. The non-conditional multivariate logistic regression analysis was used to analyze the factors that caused EH. There were no statistical differences of the basic information between two groups, such as age, body mass index, menstrual cycle, gravidity, the ratio of diabetes and hypertension and so on （P〉0.05）. The study protocal was approved by the Ethical Review Board of Investigation in Human Being of Shenzhen Baoan District Maternity ＆ Child Healthcare Hospital. All the patients signed the informed consents. Results （1） The serum RBP4, estradiol, testosterone, DHEA expression levels in group A were lower than those of group B, and the differences were statistically significant （P〈0.05）. There were no statistical differences between two groups in FSH and LH levels （P〉0.05）. （2）Non-conditional multivariate logistic regression analysis showed that serum RBP4 level （OR= 1. 564,95M CI： 7. 655- 16.54,P=0. 006） and serum testosterone level （OR= 1. 652,95%CI：1. 689-4. 156,P=0. 036） may be related to the thickness of EH. Conclusions Serum RBP4, estradiol, testosterone and DHEA levels may be associated with endometrial malignant diseases, seru

关 键 词：视黄醇结合蛋白质类 性激素 子宫内膜增生 

分 类 号：R711.74[医药卫生—妇产科学]