醋酸去氨加压素注射液术前应用对腹腔镜根治性前列腺切除术患者的临床疗效  

Clinical effects of preoperative application of desmopressin acetate injection in patients with laparoscopic radical prostatectomy

作　　者：陈家璧[1] 庄伟[1] 张冰[2] 

机构地区：[1]福建医科大学附属第二医院泌尿外科,福建泉州362000 [2]福建医科大学附属第二医院肿瘤外科,福建泉州362000

出　　处：《中国临床药理学杂志》2016年第24期2228-2230,2234,共4页The Chinese Journal of Clinical Pharmacology

基　　金：福建省泉州市科技计划基金资助项目(2014Z42)

摘　　要：目的观察醋酸去氨加压素注射液在手术前的应用对腹腔镜根治性前列腺切除术患者血清凝血因子及红细胞沉降率的影响。方法 124例局限性前列腺癌患者随机分为对照组62例与试验组62例,2组均给予常规对症治疗,对照组术前给予注射用哌拉西林钠舒巴坦钠2.5 g,每8 h滴注1次;试验组术前给予醋酸去氨加压素注射液0.35μg,每6~12 h滴注1次,2组患者均给药2次。取仰卧位,全麻进行腹腔镜根治性前列腺切除术。术后采取顺铂联合方案化疗,连用14 d。比较2组患者的临床疗效、治疗前后血清凝血因子(FⅡ、FⅦ、FⅧ、FⅨ、FⅩ)、红细胞沉降率(ESR)水平及药物不良反应发生情况。结果治疗后,对照组临床总有效率为80.65%(50/62例),试验组为93.55%(58/62例,P<0.05)。治疗后,试验组术中出血量为(552.93±56.29)m L,对照组为(760.29±78.35)m L(P<0.05)。治疗后,试验组FⅡ为(97.47±10.12)%,FⅦ为(98.54±10.47)%,FⅧ为(126.37±13.367)%,FⅨ为(103.37±11.46)%,FⅩ为(111.44±12.51)%,对照组分别为(85.25±8.67)%,(86.73±8.93)%,(116.47±12.68)%,(90.47±9.15)%,(90.57±9.26)%,差异有统计学意义(P<0.05)。试验组治疗后血清ESR为(17.94±1.84)mm·h^(-1),对照组为(26.46±3.73)mm·h^(-1)(P<0.05)。试验组药物不良反应主要表现为头痛、胃肠道反应、心动过速,药物不良反应发生率为8.06%(5/62例);对照组药物不良反应主要表现为头痛、血清肌酸酐轻度上升、胃肠道反应、皮疹,药物不良反应发生率为12.90%(8/62例),差异无统计学意义(P>0.05)。结论醋酸去氨加压素注射液在手术前的应用对腹腔镜根治性前列腺切除术患者的临床疗效显著,提高血清凝血因子,降低红细胞沉降率水平,安全性高。Objective To observe the effect of preoperative application of desmopressin acetate injection on serum coagulation factor and erythro- cyte sedimentation rate（ESR） in patients with laparoscopic radical pros- tatectomy. Methods A total of 124 patients suffering from localized prostate cancer were randomly divided into control group （n = 62 cases） and treatment group （n = 62 cases）. Both groups were received conven-tional treatment. Patients in control group were treated with injectable piperacillin sodium sulbactam sodium 2. 5 g before operation, once every 8 h. Patients in treatment group were treated with desmopressin acetate injection 0. 35 μg before operation, once every 6 - 12 h. Patients in both groups were administered with drugs for twice. General anesthesia was carried. Supine position was taken. And laparo- scopic radical prostatectomy was operated. Cisplatin combined chemotherapy was adopted after operation for 14 d. The clinical efficacy, levels of serum blood coagulation factor （F Ⅱ, FⅦ, FⅧ, FⅨ, FⅩ）, ESR and adverse drug reactions in two groups before and after treatment were compared. Results The total efficiency in control group was 80. 65% （50/62 cases）, had significant difference with that in treatment group, which was 93.55 % （58/62 cases, P 〈 0. 05 ）. After treatment, the postoperative bleeding in treatment group and control group were （552.93 ± 56. 29 ）, （760. 29 ±78. 35） mL （ P 〈0.05）. After treatment, F I I, FVII, FVI±, FIX, FX in treatment group were （97.47 ± 10. 12） %, （98.54 ± 10. 47 ） %, （ 126. 37 ± 13.367 ） %, （ 103.37 ± 11.46） %, （ 111.44 ± 12. 51 ） %, had significant difference with those in control group, which were （85.25 ± 8.67 ）%, （86.73 ± 8.93 ）%, （ 116.47 ± 12.68 ） %, （90. 47 ± 9. 15 ） %, （90.57 ± 9.26 ） % （ P 〈 0. 05 ）. After treatment, ESR in treatment group was（17.94 ± 1.84）mm·h^-1,which had significant difference with （26.46 ±3.73） mm·h^-1 in control group

关 键 词：醋酸去氨加压素注射液 腹腔镜根治性前列腺切除术 凝血因子 红细胞沉降率 

分 类 号：R983[医药卫生—药品]